| Drug General Information |
| Drug ID |
D05NKG
|
| Former ID |
DIB018827
|
| Drug Name |
alsterpaullone 2-cyanoethyl
|
| Synonyms |
alsterpaullone derivative7
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
|
| Formula |
C19H14N4O3
|
| InChI |
InChI=1S/C19H14N4O3/c20-7-1-2-11-3-5-17-15(8-11)19-14(10-18(24)21-17)13-9-12(23(25)26)4-6-16(13)22-19/h3-6,8-9,22H,1-2,10H2,(H,21,24)
|
| InChIKey |
UBLFSMURWWWWMH-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| PubChem Substance ID |
26758196, 46580825, 96043488, 99302618, 103567608, 136350633, 160854753, 163124277, 163688632, 175607453, 178102549, 180371691, 204380407, 228303105, 247156890
|
| Target and Pathway |
| Target(s) |
Cell division control protein 2 homolog |
Target Info |
Inhibitor |
[2]
|
|---|
| Glycogen synthase kinase-3 beta |
Target Info |
Inhibitor |
[2]
|
|
KEGG Pathway
|
Cell cycle
|
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Oocyte meiosis
|
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p53 signaling pathway
|
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Gap junction
|
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Progesterone-mediated oocyte maturation
|
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Herpes simplex infection
|
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Epstein-Barr virus infection
|
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Viral carcinogenesishsa04012:ErbB signaling pathway
|
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Chemokine signaling pathway
|
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PI3K-Akt signaling pathway
|
|
Wnt signaling pathway
|
|
Hedgehog signaling pathway
|
|
Axon guidance
|
|
Hippo signaling pathway
|
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Focal adhesion
|
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Signaling pathways regulating pluripotency of stem cells
|
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T cell receptor signaling pathway
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B cell receptor signaling pathway
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Neurotrophin signaling pathway
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Dopaminergic synapse
|
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Insulin signaling pathway
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Melanogenesis
|
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Prolactin signaling pathway
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Thyroid hormone signaling pathway
|
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Non-alcoholic fatty liver disease (NAFLD)
|
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Alzheimer's disease
|
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Hepatitis C
|
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Measles
|
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Influenza A
|
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HTLV-I infection
|
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Pathways in cancer
|
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Colorectal cancer
|
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Endometrial cancer
|
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Prostate cancer
|
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Basal cell carcinoma
|
|
NetPath Pathway
|
RANKL Signaling Pathway
|
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PANTHER Pathway
|
Alzheimer disease-presenilin pathway
|
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Angiogenesis
|
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Cadherin signaling pathway
|
|
Hedgehog signaling pathway
|
|
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
|
|
Insulin/IGF pathway-protein kinase B signaling cascade
|
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Interleukin signaling pathway
|
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PDGF signaling pathway
|
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PI3 kinase pathway
|
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Wnt signaling pathway
|
|
Ras Pathway
|
|
CCKR signaling map ST
|
|
Pathway Interaction Database
|
p73 transcription factor network
|
|
E2F transcription factor network
|
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PLK1 signaling events
|
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AP-1 transcription factor network
|
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FOXM1 transcription factor network
|
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Retinoic acid receptors-mediated signalinglysophospholipid_pathway:LPA receptor mediated events
|
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Degradation of beta catenin
|
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Reelin signaling pathway
|
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Presenilin action in Notch and Wnt signaling
|
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Integrin-linked kinase signaling
|
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CDC42 signaling events
|
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LKB1 signaling events
|
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Canonical Wnt signaling pathway
|
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Role of Calcineurin-dependent NFAT signaling in lymphocytes
|
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Glucocorticoid receptor regulatory network
|
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C-MYC pathway
|
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Regulation of Androgen receptor activity
|
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BMP receptor signaling
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Hedgehog signaling events mediated by Gli proteins
|
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Signaling events mediated by Stem cell factor receptor (c-Kit)
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Validated transcriptional targets of deltaNp63 isoforms
|
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Aurora A signaling
|
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Insulin-mediated glucose transport
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Class I PI3K signaling events mediated by Akt
|
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p53 pathway
|
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Trk receptor signaling mediated by PI3K and PLC-gamma
|
|
Reactome
|
MAPK3 (ERK1) activation
|
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E2F mediated regulation of DNA replication
|
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G0 and Early G1
|
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Cyclin B2 mediated events
|
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Golgi Cisternae Pericentriolar Stack Reorganization
|
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Cdc20:Phospho-APC/C mediated degradation of Cyclin A
|
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Regulation of APC/C activators between G1/S and early anaphase
|
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Phosphorylation of the APC/C
|
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Phosphorylation of Emi1
|
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Condensation of Prophase Chromosomes
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MASTL Facilitates Mitotic Progression
|
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Resolution of Sister Chromatid Cohesion
|
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Condensation of Prometaphase Chromosomes
|
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Regulation of PLK1 Activity at G2/M Transition
|
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Activation of NIMA Kinases NEK9, NEK6, NEK7
|
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Loss of Nlp from mitotic centrosomes
|
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Recruitment of mitotic centrosome proteins and complexes
|
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Loss of proteins required for interphase microtubule organization?from the centrosome
|
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Recruitment of NuMA to mitotic centrosomes
|
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Depolymerisation of the Nuclear Lamina
|
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Anchoring of the basal body to the plasma membrane
|
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MAPK6/MAPK4 signaling
|
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G1/S-Specific Transcription
|
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Cyclin A/B1 associated events during G2/M transition
|
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G2/M DNA replication checkpoint
|
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Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complexR-HSA-195253:Degradation of beta-catenin by the destruction complex
|
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AKT phosphorylates targets in the cytosol
|
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Regulation of HSF1-mediated heat shock response
|
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CRMPs in Sema3A signaling
|
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Disassembly of the destruction complex and recruitment of AXIN to the membrane
|
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S33 mutants of beta-catenin aren't phosphorylated
|
|
S37 mutants of beta-catenin aren't phosphorylated
|
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S45 mutants of beta-catenin aren't phosphorylated
|
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T41 mutants of beta-catenin aren't phosphorylated
|
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Degradation of GLI2 by the proteasome
|
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Constitutive Signaling by AKT1 E17K in Cancer
|
|
WikiPathways
|
DNA Damage Response
|
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G1 to S cell cycle control
|
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TGF beta Signaling Pathway
|
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PPAR Alpha Pathway
|
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MAP kinase activation in TLR cascade
|
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RAF/MAP kinase cascade
|
|
Mitotic Prophase
|
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Mitotic Prometaphase
|
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BMI1
|
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ATM Signaling Pathway
|
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Retinoblastoma (RB) in Cancer
|
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Spinal Cord Injury
|
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Prostate Cancer
|
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Regulation of Microtubule Cytoskeleton
|
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Integrated Cancer pathway
|
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Mitotic G2-G2/M phases
|
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Mitotic G1-G1/S phases
|
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Cell Cycle
|
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APC/C-mediated degradation of cell cycle proteins
|
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Cell Cycle Checkpoints
|
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miRNA Regulation of DNA Damage ResponseWP710:DNA Damage Response (only ATM dependent)
|
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Senescence and Autophagy in Cancer
|
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Notch Signaling Pathway
|
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Glycogen Metabolism
|
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Insulin Signaling
|
|
Wnt Signaling Pathway
|
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Wnt Signaling Pathway and Pluripotency
|
|
IL-6 signaling pathway
|
|
Wnt Signaling Pathway Netpath
|
|
Copper homeostasis
|
|
Focal Adhesion
|
|
Hair Follicle Development: Induction (Part 1 of 3)
|
|
Cardiac Hypertrophic Response
|
|
Degradation of beta-catenin by the destruction complex
|
|
T-Cell Receptor and Co-stimulatory Signaling
|
|
Cardiac Progenitor Differentiation
|
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BDNF signaling pathway
|
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Corticotropin-releasing hormone
|
|
B Cell Receptor Signaling Pathway
|
|
IL17 signaling pathway
|
|
Neural Crest Differentiation
|
|
Alzheimers Disease
|
|
IL-7 Signaling Pathway
|
|
TWEAK Signaling Pathway
|
|
Leptin signaling pathway
|
|
Semaphorin interactions
|
|
MicroRNAs in cardiomyocyte hypertrophy
|
|
Androgen receptor signaling pathway
|
|
IL-5 Signaling Pathway
|
| References |
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5926). |
|---|
| REF 2 | Proc Natl Acad Sci U S A. 2007 Dec 18;104(51):20523-8. Epub 2007 Dec 11.A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases. |
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