Drug General Information |
Drug ID |
D0NJ4H
|
Former ID |
DNC006614
|
Drug Name |
MORIN
|
Drug Type |
Small molecular drug
|
Indication |
Discovery agent
|
Investigative |
[1]
|
Structure |
|
Download
2D MOL
3D MOL
|
Formula |
C15H10O7
|
InChI |
InChI=1S/C15H10O7/c16-6-1-2-8(9(18)3-6)15-14(21)13(20)12-10(19)4-7(17)5-11(12)22-15/h1-5,16-19,21H
|
InChIKey |
YXOLAZRVSSWPPT-UHFFFAOYSA-N
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PubChem Compound ID |
|
PubChem Substance ID |
12291, 82595, 597188, 855692, 3133996, 4350240, 8138036, 8149869, 8616709, 11111456, 11336133, 11361372, 11364128, 11366690, 11369252, 11372921, 11375406, 11377414, 11406040, 11462344, 11484665, 11488531, 11491756, 11493738, 11495048, 11537743, 12161501, 14776187, 17405337, 24885989, 26612364, 26680105, 26746965, 26746966, 29204411, 39290452, 47365282, 47515389, 47515390, 47736574, 47736575, 48110526, 48259328, 48421904, 49748184, 49970076, 50100276, 50104016, 50104017, 50104018
|
Target and Pathway |
Target(s) |
Estrogen receptor beta |
Target Info |
Inhibitor |
[2]
|
Beta-hydroxyacyl-acp dehydratase |
Target Info |
Inhibitor |
[3]
|
Solute carrier family 22 member 12 |
Target Info |
Inhibitor |
[4]
|
Fatty acid synthase |
Target Info |
Inhibitor |
[3]
|
3-oxoacyl-[acyl-carrier protein] reductase |
Target Info |
Inhibitor |
[3]
|
Induced myeloid leukemia cell differentiation protein Mcl-1 |
Target Info |
Inhibitor |
[2]
|
Enoyl-ACP reductase |
Target Info |
Inhibitor |
[3]
|
BioCyc Pathway
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Fatty acid biosynthesis initiation
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Fatty acid elongation -- saturated
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Palmitate biosynthesis
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KEGG Pathway
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Estrogen signaling pathway
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Prolactin signaling pathwaypfa00061:Fatty acid biosynthesis
|
Biotin metabolism
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Metabolic pathways
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Fatty acid metabolismhsa00061:Fatty acid biosynthesis
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Metabolic pathways
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Fatty acid metabolism
|
AMPK signaling pathway
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Insulin signaling pathwayhsa04151:PI3K-Akt signaling pathway
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MicroRNAs in cancer
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NetPath Pathway
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TCR Signaling Pathway
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PANTHER Pathway
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Apoptosis signaling pathway
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CCKR signaling map ST
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Pathway Interaction Database
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Plasma membrane estrogen receptor signaling
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Validated nuclear estrogen receptor beta network
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Validated nuclear estrogen receptor alpha networkp73pathway:p73 transcription factor network
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Validated transcriptional targets of deltaNp63 isoformse2f_pathway:E2F transcription factor network
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Direct p53 effectors
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IL6-mediated signaling events
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HIF-1-alpha transcription factor network
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PathWhiz Pathway
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Fatty Acid Biosynthesis
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Reactome
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Nuclear Receptor transcription pathwayR-HSA-163765:ChREBP activates metabolic gene expression
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Activation of gene expression by SREBF (SREBP)
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Fatty Acyl-CoA Biosynthesis
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WikiPathways
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SIDS Susceptibility Pathways
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Ovarian Infertility Genes
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Integrated Pancreatic Cancer Pathway
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Nuclear ReceptorsWP1935:Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compoundsWP357:Fatty Acid Biosynthesis
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Nuclear Receptors Meta-Pathway
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Liver X Receptor Pathway
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Activation of Gene Expression by SREBP (SREBF)
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SREBF and miR33 in cholesterol and lipid homeostasis
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SREBP signalling
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Metabolism of water-soluble vitamins and cofactors
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Integration of energy metabolism
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Fatty acid, triacylglycerol, and ketone body metabolism
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AMPK SignalingWP254:Apoptosis
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miR-targeted genes in muscle cell - TarBase
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miR-targeted genes in lymphocytes - TarBase
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miR-targeted genes in leukocytes - TarBase
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Apoptosis Modulation and Signaling
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References |
REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 411). |
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REF 2 | Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6. Epub 2010 Oct 21.In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2). |
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REF 3 | J Med Chem. 2006 Jun 1;49(11):3345-53.Inhibition of Plasmodium falciparum fatty acid biosynthesis: evaluation of FabG, FabZ, and FabI as drug targets for flavonoids. |
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REF 4 | Drug Metab Dispos. 2007 Jun;35(6):981-6. Epub 2007 Feb 26.Morin (3,5,7,2',4'-pentahydroxyflavone) exhibits potent inhibitory actions on urate transport by the human urate anion transporter (hURAT1) expressed in human embryonic kidney cells. |