Drug Information

Drug General Information
Drug ID
D0V3TO
Former ID
DNC006977
Drug Name
JWH-348
Drug Type
Small molecular drug
Indication Discovery agent Investigative [528355]
Structure
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2D MOL

3D MOL
Formula
C27H24F3NO
Canonical SMILES
CCCCCN1C=C(C=C1C2=CC=C(C=C2)C(F)(F)F)C(=O)C3=CC=CC4=CC=<br />CC=C43
InChI
1S/C27H24F3NO/c1-2-3-6-16-31-18-21(17-25(31)20-12-14-22(15-13-20)27(28,29)30)26(32)24-11-7-9-19-8-4-5-10-23(19)24/h4-5,7-15,17-18H,2-3,6,16H2,1H3
InChIKey
KFMFBZYLXNTONN-UHFFFAOYSA-N
PubChem Compound ID
44418368
Target and Pathway
Target(s) Cannabinoid receptor 2 Target Info Inhibitor [528355]
Cannabinoid receptor 1 Target Info Inhibitor [528355]
KEGG Pathway Neuroactive ligand-receptor interactionhsa04015:Rap1 signaling pathway
Neuroactive ligand-receptor interaction
Retrograde endocannabinoid signaling
PANTHER Pathway Endogenous cannabinoid signaling
Pathway Interaction Database N-cadherin signaling events
Reactome Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling eventsR-HSA-373076:Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Small Ligand GPCRs
GPCR ligand binding
GPCR downstream signalingWP455:GPCRs, Class A Rhodopsin-like
BDNF signaling pathway
GPCR downstream signaling
GPCRs, Other
References
Ref 528355Bioorg Med Chem Lett. 2006 Oct 15;16(20):5432-5. Epub 2006 Aug 4.1-Alkyl-2-aryl-4-(1-naphthoyl)pyrroles: new high affinity ligands for the cannabinoid CB1 and CB2 receptors.
Ref 528355Bioorg Med Chem Lett. 2006 Oct 15;16(20):5432-5. Epub 2006 Aug 4.1-Alkyl-2-aryl-4-(1-naphthoyl)pyrroles: new high affinity ligands for the cannabinoid CB1 and CB2 receptors.

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