Drug General Information
Drug ID
D0U9QD
Former ID
DIB018676
Drug Name
6-fluorotryptophan
Drug Type
Small molecular drug
Indication Discovery agent Investigative [468191]
Structure
Download
2D MOL
Formula
C11H11FN2O2
InChI
InChI=1S/C11H11FN2O2/c12-7-1-2-8-6(3-9(13)11(15)16)5-14-10(8)4-7/h1-2,4-5,9,14H,3,13H2,(H,15,16)
InChIKey
YMEXGEAJNZRQEH-UHFFFAOYSA-N
PubChem Compound ID
PubChem Substance ID
Target and Pathway
Target(s) L-Tryptophan hydroxylase 2 Target Info Inhibitor [533554]
Tryptophan 5-hydroxylase-1 Target Info Inhibitor [533554]
BioCyc Pathway Superpathway of tryptophan utilization
Serotonin and melatonin biosynthesis
KEGG Pathway Tryptophan metabolism
Metabolic pathways
Serotonergic synapse
PANTHER Pathway 5-Hydroxytryptamine biosynthesis
PathWhiz Pathway Tryptophan Metabolism
WikiPathways SIDS Susceptibility Pathways
Biogenic Amine Synthesis
Tryptophan metabolism
Metabolism of amino acids and derivatives
References
Ref 468191(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5126).
Ref 533554(+)-6-fluorotryptophan, an inhibitor of tryptophan hydroxylase: sleep and wakefulness in the rat. Neuropharmacology. 1981 Apr;20(4):335-9.

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