Drug Information

Drug General Information
Drug ID
D0KR2J
Former ID
DAP000697
Drug Name
Entecavir
Synonyms
Baraclude; ETV; Entecavir hydrate; Entecavir monohydrate; BMS-200475; Baraclude (TN); Entecavir (INN); Entecavir (USAN); Entecavir hydrate (JAN); SQ-34676; 2-amino-1,9-dihydro-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-methylenecyclopentyl]-6H-purin-6-one; 2-amino-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-methylidenecyclopentyl]-1,9-dihydro-6H-purin-6-one; 2-amino-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-methylidenecyclopentyl]-1,9-dihydro-6H-purin-6-one-water (1/1); 2-amino-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-methylidenecyclopentyl]-3H-purin-6-one; 6-H-Purin-6-one-,2-amino-1,9-dihydro-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-methylenecyclopentyl]; 9-((1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-methylenecyclopentyl)guanine monohydrate
Drug Type
Small molecular drug
Indication HBV infection [ICD9: 070.2-070.3; ICD10:B16, B18.0, B18.1] Approved [536361]
Therapeutic Class
Antiviral Agents
Company
Bristol-Myers Squibb
Structure
Download
2D MOL

3D MOL
Formula
C12H17N5O4
Canonical SMILES
C=C1C(CC(C1CO)O)N2C=NC3=C2NC(=NC3=O)N.O
InChI
1S/C12H15N5O3.H2O/c1-5-6(3-18)8(19)2-7(5)17-4-14-9-10(17)15-12(13)16-11(9)20;/h4,6-8,18-19H,1-3H2,(H3,13,15,16,20);1H2/t6-,7-,8-;/m0./s1
InChIKey
YXPVEXCTPGULBZ-WQYNNSOESA-N
CAS Number
CAS 142217-69-4
PubChem Compound ID
16052026
PubChem Substance ID
17398002, 37101953, 49830936, 56391942, 57379683, 91749140, 99319526, 104253461, 118313779, 124757591, 125001900, 125164395, 126651626, 134222146, 136920321, 137129051, 137179356, 152034465, 162011500, 162183301, 163370951, 163908003, 164825059, 164833113, 172087090, 172440023, 174531851, 175265673, 180672743, 186013131, 196106268, 198991663, 210274904, 210280539, 223379249, 223398838, 226415922, 249739265, 251893489, 252110220, 252162333, 252316076
SuperDrug ATC ID
J05AF10
Drug Resistance Mutation (DRM)
DRM DRM Info
Target and Pathway
Target(s) DNA polymerase/reverse transcriptase Target Info Modulator [532700]
References
Ref 536361Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. Epub 2007 Feb 20.
Ref 532700Effect of hepatitis B virus reverse transcriptase variations on entecavir treatment response. J Infect Dis. 2014 Sep 1;210(5):701-7.

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