Drug Information

Drug General Information
Drug ID
D0X5ZI
Former ID
DAP001441
Drug Name
Ambrisentan
Synonyms
Letairis; Ambrisentan [INN]; Gilead brand of ambrisentan; BSF 208075; BSF208075; LU 208075; LU208075; BSF-208075; LU-208075; Benzenepropanoic acid, .alpha.-[(4,6-dimethyl-2-pyrimidinyl)oxy]-.beta.-methoxy-.beta.-phe; (+-)-(2S)-2-((4,6-Dimethylpyrimidin-2-yl)oxy)-3-methoxy-3,3-diphenylpropanoic acid; 2-(4,6-dimethylpyrimidin-2-yl)oxy-3-methoxy-3,3-diphenyl-propanoic acid; 2-(4,6-dimethylpyrimidin-2-yl)oxy-3-methoxy-3,3-diphenylpropanoic acid; 2-[(4,6-dimethylpyrimidin-2-yl)oxy]-3-methoxy-3,3-diphenylpropanoic acid
Drug Type
Small molecular drug
Indication Pulmonary arterial hypertension [ICD9: 416; ICD10:I27.0, I27.2] Approved [536294], [540573]
Company
GSK
Structure
Download
2D MOL

3D MOL
Formula
C22H22N2O4
InChI
InChI=1S/C22H22N2O4/c1-15-14-16(2)24-21(23-15)28-19(20(25)26)22(27-3,17-10-6-4-7-11-17)18-12-8-5-9-13-18/h4-14,19H,1-3H3,(H,25,26)/t19-/m1/s1
InChIKey
OUJTZYPIHDYQMC-LJQANCHMSA-N
CAS Number
CAS 177036-94-1
PubChem Compound ID
6918493
PubChem Substance ID
12015371, 14779987, 17194924, 43529863, 50551569, 51091419, 53787770, 57371956, 93309673, 103307060, 104035299, 114788055, 118855302, 126616865, 126651844, 131302629, 134338642, 135692418, 137237404, 139988399, 143497715, 144205520, 152133959, 152238501, 152258462, 160647297, 160826914, 162011508, 162172038, 163093066, 163387054, 164824132, 170465143, 174007223, 175267375, 175426501, 178100778, 179116973, 185986582, 187071933, 196107821, 198977886, 198991664, 204430246, 211534802, 223375980, 223532574, 223704800, 224518792, 226395806
SuperDrug ATC ID
C02KX02
Target and Pathway
Target(s) Endothelin-1 receptor Target Info Antagonist [550963]
KEGG Pathway Calcium signaling pathway
cGMP-PKG signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Vascular smooth muscle contraction
Renin secretion
Pathways in cancer
NetPath Pathway IL4 Signaling Pathway
PANTHER Pathway Endothelin signaling pathway
Pathway Interaction Database Endothelins
EGFR-dependent Endothelin signaling events
Reactome Peptide ligand-binding receptors
G alpha (q) signalling events
WikiPathways Prostaglandin Synthesis and Regulation
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Peptide GPCRs
Endothelin Pathways
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 536294Emerging treatments for pulmonary arterial hypertension. Expert Opin Emerg Drugs. 2006 Nov;11(4):609-19.
Ref 540573(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3951).
Ref 550963Clinical pipeline report, company report or official report of GlaxoSmithKline (2009).

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