Drug General Information
Drug ID
D0A2UV
Former ID
DCL001030
Drug Name
Ustekinumab
Synonyms
Stelara (TN)
Drug Type
Antibody
Indication Moderate-to-severe plaque psoriasis [ICD9: 696; ICD10:L40] Approved [530677], [541942]
Psoriasis [ICD9: 696; ICD10:L40] Phase 3 [530677], [541942]
Crohn's disease; Inflammatory bowel disease [ICD9: 555, 556; ICD10:K50, K51] Phase 2/3 [530677], [541942]
Company
Centocor Ortho Biotech
Structure
Download
2D MOL

3D MOL

Formula
C14H18Cl3N5O2
PubChem Compound ID
SuperDrug ATC ID
L04AC05
Target and Pathway
Target(s) Interleukin-23 ligand Target Info [530677], [536371], [537117]
Interleukin-12 Target Info [530677], [536371], [537117]
KEGG Pathway Cytokine-cytokine receptor interaction
Toll-like receptor signaling pathway
RIG-I-like receptor signaling pathway
Jak-STAT signaling pathway
Type I diabetes mellitus
Pertussis
Legionellosis
Leishmaniasis
Chagas disease (American trypanosomiasis)
African trypanosomiasis
Malaria
Toxoplasmosis
Amoebiasis
Tuberculosis
Measles
Influenza A
Herpes simplex infection
Inflammatory bowel disease (IBD)
Allograft rejectionhsa04060:Cytokine-cytokine receptor interaction
Allograft rejection
Pathway Interaction Database IL27-mediated signaling events
IL12-mediated signaling events
WikiPathways Toll-like receptor signaling pathway
Aryl Hydrocarbon Receptor Pathway
Allograft Rejection
Regulation of toll-like receptor signaling pathwayWP75:Toll-like receptor signaling pathway
Regulation of toll-like receptor signaling pathway
References
Ref 530677Hughes B: 2009 FDA drug approvals. Nat Rev Drug Discov. 2010 Feb;9(2):89-92.
Ref 541942(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6885).
Ref 530677Hughes B: 2009 FDA drug approvals. Nat Rev Drug Discov. 2010 Feb;9(2):89-92.
Ref 536371Emerging drugs to treat Crohn's disease. Expert Opin Emerg Drugs. 2007 Mar;12(1):49-59.
Ref 537117Emerging drugs for psoriasis. Expert Opin Emerg Drugs. 2009 Mar;14(1):145-63.

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