Drug Information

Drug General Information
Drug ID
D0Z9EO
Former ID
DNCL002890
Drug Name
Metreleptin
Indication Diabetes; Hypertriglyceridemia [ICD9: 250, 272.1, 272.6; ICD10:E08-E13, E78.1, E78.2, E78.3, E88.1] Approved [542357], [550293]
Company
Amylin Pharmaceuticals
Target and Pathway
Target(s) Leptin receptor Target Info Modulator [533123]
KEGG Pathway Cytokine-cytokine receptor interaction
Neuroactive ligand-receptor interaction
AMPK signaling pathway
Jak-STAT signaling pathway
Adipocytokine signaling pathway
Non-alcoholic fatty liver disease (NAFLD)
Pathway Interaction Database Signaling events mediated by PTP1B
WikiPathways Leptin signaling pathway
AMPK Signaling
References
Ref 542357(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7333).
Ref 550293US FDA approves orphan drug MYALEPT? (metreleptin for injection)
Ref 5331232014 FDA drug approvals. Nat Rev Drug Discov. 2015 Feb;14(2):77-81.

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