Drug General Information
Drug ID	D0R4ZT
Former ID	DAP001096
Drug Name	Gallium nitrate
Synonyms	Ganite (TN)
Drug Type	Small molecular drug
Indication	Hypercalcemia [ICD9: 275.42; ICD10:E83.5]		Approved	[550703]
Therapeutic Class	Anticancer Agents
Structure		Download 2D MOL 3D MOL
Formula	GaN3O9
Canonical SMILES	[N+](=O)([O-])[O-].[N+](=O)([O-])[O-].[N+](=O)([O-])[O-<br />].[Ga+3]
InChI	1S/Ga.3NO3/c;3*2-1(3)4/q+3;3*-1
InChIKey	CHPZKNULDCNCBW-UHFFFAOYSA-N
CAS Number	CAS 13494-90-1
PubChem Compound ID	61635
PubChem Substance ID	8136941, 8187642, 15490402, 43118883, 46508923, 49972104, 53787129, 57314462, 80293189, 104323852, 125332325, 125823143, 134338345, 135017186, 137008685, 152041776, 160967841, 176269487, 179322711, 198935959, 223753512, 251892768, 252508831
Target and Pathway
Target(s)	Interleukin-1 beta	Target Info	Inhibitor	[536132]
KEGG Pathway	MAPK signaling pathway
	Cytokine-cytokine receptor interaction
	NF-kappa B signaling pathway
	Apoptosis
	Osteoclast differentiation
	Toll-like receptor signaling pathway
	NOD-like receptor signaling pathway
	Cytosolic DNA-sensing pathway
	Hematopoietic cell lineage
	TNF signaling pathway
	Inflammatory mediator regulation of TRP channels
	Non-alcoholic fatty liver disease (NAFLD)
	Type I diabetes mellitus
	Alzheimer's disease
	Prion diseases
	Salmonella infection
	Pertussis
	Legionellosis
	Leishmaniasis
	Chagas disease (American trypanosomiasis)
	African trypanosomiasis
	Malaria
	Amoebiasis
	Tuberculosis
	Measles
	Influenza A
	Herpes simplex infection
	Inflammatory bowel disease (IBD)
	Rheumatoid arthritis
	Graft-versus-host disease
NetPath Pathway	Leptin Signaling Pathway
	IL5 Signaling Pathway
	IL1 Signaling Pathway
	IL2 Signaling Pathway
	IL3 Signaling Pathway
	TGF_beta_Receptor Signaling Pathway
	Wnt Signaling Pathway
	TCR Signaling Pathway
	TNFalpha Signaling Pathway
Pathway Interaction Database	IL27-mediated signaling events
	IL12-mediated signaling events
	IL1-mediated signaling events
	IFN-gamma pathway
	IL23-mediated signaling events
	Cellular roles of Anthrax toxin
Reactome	Interleukin-1 signaling
	Interleukin-1 processing
	CLEC7A/inflammasome pathway
WikiPathways	Toll-like receptor signaling pathway
	Monoamine Transport
	SIDS Susceptibility Pathways
	TCR Signaling Pathway
	Type II interferon signaling (IFNG)
	Senescence and Autophagy in Cancer
	Cytokines and Inflammatory Response
	MAPK Signaling Pathway
	Myometrial Relaxation and Contraction Pathways
	Aryl Hydrocarbon Receptor Pathway
	IL1 and megakaryotyces in obesity
	Hematopoietic Stem Cell Differentiation
	Spinal Cord Injury
	Allograft Rejection
	Alzheimers Disease
	Leptin signaling pathway
	IL-1 signaling pathway
	Interleukin-1 signaling
	Folate Metabolism
	Vitamin B12 Metabolism
	Selenium Micronutrient Network
	Serotonin Transporter Activity
	Regulation of toll-like receptor signaling pathway
	NOD pathway
References
Ref 550703	Drug information of Gallium nitrate, 2008. eduDrugs.
Ref 536132	Elimination of arthritis pain and inflammation for over 2 years with a single 90 min, topical 14% gallium nitrate treatment: case reports and review of actions of gallium III. Med Hypotheses. 2005;65(6):1136-41. Epub 2005 Aug 24.

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