Drug Information

Drug General Information
Drug ID
D08CTT
Former ID
DAP001366
Drug Name
Dimethindene
Synonyms
Dimethpyrindene; Dimethylpyrindene; Dimetindene; Dimetindeno; Dimetindenum; Fengel; Fenistil; Forhistal; Foristal; Pecofenil; Triten; Z 2001; Dimetindene (INN); Dimetindene [INN:BAN]; Dimetindeno [INN-Spanish]; Dimetindenum [INN-Latin]; Fenistil (TN); Dimethyl{2-[3-(2-pyridylethyl)inden-2-yl]ethyl}amine; N,N-Dimethyl-3-(1-(2-pyridyl)ethyl)inden-2-ethylamin; N,N-Dimethyl-N-(3-(1-(2-pyridyl)ethyl)-2-indenylethyl)amin; N,N-dimethyl-2-[3-(1-pyridin-2-ylethyl)-1H-inden-2-yl]ethanamine; (+/-)-Dimethindene; 1H-Indene-2-ethanamine, N,N-dimethyl-3-(1-(2-pyridinyl)ethyl)-(9CI); 2-(1-(2-(2-Dimethylaminoethyl)inden-3-yl)ethyl)pyridine
Drug Type
Small molecular drug
Indication Respiratory allergies; Allergic rhinitis [ICD9: 460-519, 472.0, 477, 995.3; ICD10:J00-J99, J00, J30, J31.0, T78.4] Approved [535933], [551871]
Therapeutic Class
Antiallergic Agents
Structure
Download
2D MOL

3D MOL
Formula
C20H24N2
Canonical SMILES
CC(C1=CC=CC=N1)C2=C(CC3=CC=CC=C32)CCN(C)C
InChI
1S/C20H24N2/c1-15(19-10-6-7-12-21-19)20-17(11-13-22(2)3)14-16-8-4-5-9-18(16)20/h4-10,12,15H,11,13-14H2,1-3H3
InChIKey
MVMQESMQSYOVGV-UHFFFAOYSA-N
CAS Number
CAS 5636-83-9
PubChem Compound ID
21855
PubChem Substance ID
615229, 7547415, 8166093, 10527461, 16889015, 29289221, 48415902, 49833540, 50032411, 57331006, 75533068, 96024549, 99445271, 103188199, 104354442, 117521890, 119525888, 126410956, 128653820, 131342026, 134224440, 134338577, 134987134, 137113985, 141522592, 142679137, 152104464, 160969708, 179225227, 184545933, 226408700, 249924793, 252348299
SuperDrug ATC ID
D04AA13; R06AB03
SuperDrug CAS ID
cas=005636839
Target and Pathway
Target(s) Histamine H1 receptor Target Info Antagonist [535859], [535933], [537168], [537884]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Inflammatory mediator regulation of TRP channels
PANTHER Pathway Histamine H1 receptor mediated signaling pathway
Reactome Histamine receptors
G alpha (q) signalling events
WikiPathways Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
IL-4 Signaling Pathway
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 535933Prescription and safety of dimethindene maleate micropellet capsules in Hungary. Orv Hetil. 2004 Feb 15;145(7):327-9.
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 535859Effects of dimethindene maleate nasal spray on the quality of life in seasonal allergic rhinitis. Rhinology. 2003 Sep;41(3):159-66.
Ref 535933Prescription and safety of dimethindene maleate micropellet capsules in Hungary. Orv Hetil. 2004 Feb 15;145(7):327-9.
Ref 537168Analytical method for simultaneously measuring ex vivo drug receptor occupancy and dissociation rate: application to (R)-dimethindene occupancy of central histamine H1 receptors. J Recept Signal Transduct Res. 2009;29(2):84-93.
Ref 537884Inhibition by histamine H1 receptor antagonists of endogenous glibenclamide-sensitive K+ channels in follicle-enclosed Xenopus oocytes. Eur J Pharmacol. 1994 Jan 1;266(1):99-102.

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