Drug Information

Drug General Information
Drug ID
D08VRO
Former ID
DAP001394
Drug Name
Ketanserin
Synonyms
Ketanserina; Ketanserine; Ketanserinum; Ketaserin; Perketal; Serefrex; Sufrexal; Taseron; Ketanserina [INN-Spanish]; Ketanserine [INN-French]; Ketanserinum [INN-Latin]; R 41,468; R-41468; [3H]-Ketanserin; Ketanserin (USAN/INN); Ketanserin [USAN:BAN:INN]; R-41,468; (+)-3-[2-[4-(4-Fluorobenzoyl)-1-piperidinyl]ethyl]-2,4(1H,3H)-quinazolinedione; 3-(2-(4-(4-Fluorobenzoyl)piperidinol)ethyl)-2,4(1H,3H)-quinazolinedione; 3-(2-(4-(p-Fluorobenzoyl)piperidino)ethyl)-2,4-(1H,3H)-quinazolinedione; 3-(2-{4-[(4-fluorophenyl)carbonyl]piperidin-1-yl}ethyl)quinazoline-2,4(1H,3H)-dione; 3-[2-[4-(4-fluorobenzoyl)-1-piperidyl]ethyl]-1H-quinazoline-2,4-dione; 3-[2-[4-(4-fluorobenzoyl)piperidin-1-yl]ethyl]-1H-quinazoline-2,4-dione; 3-{2-[4-(4-fluorobenzoyl)piperidin-1-yl]ethyl}quinazoline-2,4(1H,3H)-dione
Drug Type
Small molecular drug
Indication Hypertension [ICD9: 401; ICD10:I10-I16] Approved [536361], [543270]
Therapeutic Class
Antihypertensive Agents
Company
Janssen Pharmaceutica
Structure
Download
2D MOL

3D MOL
Formula
C22H22FN3O3
InChI
InChI=1S/C22H22FN3O3/c23-17-7-5-15(6-8-17)20(27)16-9-11-25(12-10-16)13-14-26-21(28)18-3-1-2-4-19(18)24-22(26)29/h1-8,16H,9-14H2,(H,24,29)
InChIKey
FPCCSQOGAWCVBH-UHFFFAOYSA-N
CAS Number
CAS 74050-98-9
PubChem Compound ID
3822
PubChem Substance ID
9667, 5316930, 7849422, 7979679, 8152420, 11113781, 11485462, 11489529, 12013738, 14756745, 26612919, 26680573, 26747132, 26747133, 26751962, 29222941, 47440431, 47440432, 47810935, 47959944, 48416147, 49658635, 49689467, 49689468, 49698468, 50041095, 50103875, 50104634, 50284786, 53789966, 57322008, 81041139, 85209483, 85787802, 85788847, 90340810, 91011753, 92124961, 92308193, 92309154, 92719783, 103167043, 103857213, 104171396, 104304625, 118842179, 124360771, 124637348, 124757882, 124886722
ChEBI ID
ChEBI:6123
SuperDrug ATC ID
C02KD01
SuperDrug CAS ID
cas=074050989
Target and Pathway
Target(s) 5-hydroxytryptamine 2 receptor Target Info Antagonist [535863]
References
Ref 536361Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. Epub 2007 Feb 20.
Ref 543270(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 88).
Ref 535863Nordexfenfluramine causes more severe pulmonary vasoconstriction than dexfenfluramine. Am J Physiol Lung Cell Mol Physiol. 2004 Mar;286(3):L531-8. Epub 2003 Nov 7.

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