Drug Information

Drug General Information
Drug ID
D0CF2Q
Former ID
DAP000570
Drug Name
Levamisole
Synonyms
Ketrax; LEVOMYSOL; Lepuron; Levamisol; Levamisolum; Levotetramisole; Tetramisol; Wormicid; Levamisole Base;Nilverm base; P00039; Vermisol 150; Dl-Tetramisol; Dl-Tetramisole; Ergamisol (TN); Ketrax (TN); L-Tetramisole; Levamisol [INN-Spanish]; Levamisole (INN); Levamisole [INN:BAN]; Levamisolum [INN-Latin]; TCMDC-125847; L(-)-Levamisole; L-2,3,5,6-Tetrahyro-6-phenylimidazo(2,1-b)thiazole; (-)-Tetramisole; (6S)-6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b][1,3]thiazole; (S)-(-)-Levamisole
Drug Type
Small molecular drug
Indication Anthelmintic [ICD10:B89] Approved [551871]
Colon cancer [ICD9: 153, 154; ICD10:C50] Withdrawn from market [536772], [542225]
Therapeutic Class
Anticancer Agents
Company
Janssen Pharmaceutica
Structure
Download
2D MOL

3D MOL
Formula
C11H12N2S
InChI
InChI=1S/C11H12N2S/c1-2-4-9(5-3-1)10-8-13-6-7-14-11(13)12-10/h1-5,10H,6-8H2/t10-/m1/s1
InChIKey
HLFSDGLLUJUHTE-SNVBAGLBSA-N
CAS Number
CAS 14769-73-4
PubChem Compound ID
26879
PubChem Substance ID
9282, 602395, 7979761, 8169434, 10322011, 11335842, 11361081, 11364503, 11367065, 11369627, 11371883, 11374574, 11377789, 11405871, 11462053, 11466210, 11467330, 11484645, 11485760, 11488681, 11490777, 11492892, 11495423, 14748767, 15171780, 34669469, 46509052, 47440260, 47589003, 47736487, 47736488, 48035125, 48416165, 49761633, 49831041, 49981671, 50111118, 53790505, 56313649, 56313755, 57310333, 76000434, 85789251, 85860304, 90341409, 92309280, 92717075, 93166530, 96024804, 103523408
SuperDrug ATC ID
P02CE01
SuperDrug CAS ID
cas=014769734
Target and Pathway
Target(s) Alkaline phosphatase, tissue-nonspecific Target Info Inhibitor [536820]
KEGG Pathway Folate biosynthesis
Metabolic pathways
NetPath Pathway FSH Signaling Pathway
PathWhiz Pathway Vitamin B6 Metabolism
WikiPathways Endochondral Ossification
BDNF signaling pathway
AGE/RAGE pathway
References
Ref 536772New drugs in development for the treatment of endometriosis. Expert Opin Investig Drugs. 2008 Aug;17(8):1187-202.
Ref 542225(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7210).
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 536820Characterization of rat heart alkaline phosphatase isoenzymes and modulation of activity. Braz J Med Biol Res. 2008 Jul;41(7):600-9.

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