TTD | Drug: D09SSC

Drug General Information
Drug ID	D09SSC
Former ID	DIB009016
Drug Name	Nipradilol
Drug Type	Small molecular drug
Indication	Angina pectoris [ICD9: 413; ICD10:I20]		Approved	[551871]
Structure		Download 2D MOL 3D MOL
Formula	C15H22N2O6
Canonical SMILES	[N+](=O)(OC1Cc2c(OC1)c(OCC(CNC(C)C)O)ccc2)[O-]
PubChem Compound ID	72006
Target and Pathway
Target(s)	Beta-3 adrenergic receptor	Target Info	Modulator	[533522], [551871]
KEGG Pathway	Calcium signaling pathway
	cGMP-PKG signaling pathway
	Neuroactive ligand-receptor interaction
	Endocytosis
	Salivary secretion
PANTHER Pathway	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
PANTHER Pathway	Beta3 adrenergic receptor signaling pathway
Reactome	Adrenoceptors
Reactome	G alpha (s) signalling events
WikiPathways	Monoamine GPCRs
	Calcium Regulation in the Cardiac Cell
	GPCRs, Class A Rhodopsin-like
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 551871	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 533522	Actions of nipradilol (K-351), a new alpha- and beta-adrenoceptor blocker, on the rabbit portal vein. Jpn J Pharmacol. 1984 Aug;35(4):359-69.
Ref 551871	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015

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Drug Information