Drug Information

Drug General Information
Drug ID
D0XX6Y
Former ID
DAP000353
Drug Name
Pipecuronium
Synonyms
Arduan; Pipecurium; Arduan (TN); Piperazinium, 4,4'-((2beta,3alpha,5alpha,16beta,17beta)-3,17-bis(acetyloxy)androstane-2,16-diyl)bis(1,1-dimethyl); [(2S,3S,5S,8R,9S,10S,13S,14S,16S,17R)-17-acetyloxy-2,16-bis(4,4-dimethylpiperazin-4-ium-1-yl)-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl] acetate
Drug Type
Small molecular drug
Indication Spasms; Pain [ICD9: 338,780; ICD10:R52, G89] Approved [538529], [551871]
Therapeutic Class
Analgesics
Structure
Download
2D MOL

3D MOL
Formula
C35H62N4O4+2
Canonical SMILES
CC(=O)OC1CC2CCC3C(C2(CC1N4CC[N+](CC4)(C)C)C)CCC5(C3CC(C<br />5OC(=O)C)N6CC[N+](CC6)(C)C)C
InChI
1S/C35H62N4O4/c1-24(40)42-32-21-26-9-10-27-28(35(26,4)23-31(32)37-15-19-39(7,8)20-16-37)11-12-34(3)29(27)22-30(33(34)43-25(2)41)36-13-17-38(5,6)18-14-36/h26-33H,9-23H2,1-8H3/q+2/t26-,27+,28-,29-,30-,31-,32-,33-,34-,35-/m0/s1
InChIKey
OWWLUIWOFHMHOQ-XGHATYIMSA-N
CAS Number
CAS 68399-58-6
PubChem Compound ID
50192
PubChem Substance ID
9757, 14764962, 34714781, 46508493, 50065067, 57313256, 76709548, 92729638, 104294032, 134337664, 135009826, 136283313, 137005291, 160964633, 175268160, 179150546, 223440674, 226692373, 242111127
Target and Pathway
Target(s) Neuronal acetylcholinereceptor subunit alpha-2 Target Info Antagonist [536781]
KEGG Pathway Neuroactive ligand-receptor interaction
PANTHER Pathway Nicotinic acetylcholine receptor signaling pathway
Reactome Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
Highly calcium permeable nicotinic acetylcholine receptors
WikiPathways Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
References
Ref 538529FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 019638.
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 536781Synergy between pairs of competitive antagonists at adult human muscle acetylcholine receptors. Anesth Analg. 2008 Aug;107(2):525-33.

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