Drug Information

Drug General Information
Drug ID
D0L5YV
Former ID
DAP000947
Drug Name
Salmeterol
Synonyms
Aeromax; Astmerole; SALMATEROL; Salmeterolum; Serevent; Glaxo Wellcome brand of salmeterol xinafoate; Salmeterolum [Latin]; GR 33343X; S 2692; GR-33343X; Serevent (TN); Salmeterol (USAN/INN); Salmeterol [USAN:BAN:INN]; (+-)-4-Hydroxy-alpha'-(((6-(4-phenylbutoxy)hexyl)amino)methyl)-m-xylene-alpha,alpha'-diol; (+-)-4-Hydroxy-alpha1-(((6-(4-phenylbutoxy)hexyl)amino)methyl)-1,3-benzenedimethanol; (inverted question mark) 4-Hydroxy-a1-[[[6-(4-phenylbutoxy)hexyl]amino]m-ethyl]-1,3-benzenedimethanol; 2-(hydroxymethyl)-4-(1-hydroxy-2-{[6-(4-phenylbutoxy)hexyl]amino}ethyl)phenol; 2-(hydroxymethyl)-4-[1-hydroxy-2-({6-[(4-phenylbutyl)oxy]hexyl}amino)ethyl]phenol; 2-(hydroxymethyl)-4-[1-hydroxy-2-[6-(4-phenylbutoxy)hexylamino]ethyl]phenol
Drug Type
Small molecular drug
Indication Chronic obstructive pulmonary disease [ICD9: 490-492, 494-496; ICD10:J40-J44, J47] Approved [536361], [540957]
Therapeutic Class
Bronchodilator Agents
Company
GlaxoSmithKline
Structure
Download
2D MOL

3D MOL
Formula
C25H37NO4
InChI
InChI=1S/C25H37NO4/c27-20-23-18-22(13-14-24(23)28)25(29)19-26-15-7-1-2-8-16-30-17-9-6-12-21-10-4-3-5-11-21/h3-5,10-11,13-14,18,25-29H,1-2,6-9,12,15-17,19-20H2
InChIKey
GIIZNNXWQWCKIB-UHFFFAOYSA-N
CAS Number
CAS 89365-50-4
PubChem Compound ID
5152
PubChem Substance ID
9450, 5589238, 8153167, 14904552, 26719802, 29224214, 46387005, 46508024, 47207453, 47285409, 47656610, 47879637, 47953971, 48416530, 49681577, 49699219, 49879821, 50104924, 50762271, 53787866, 56311603, 56413059, 57322628, 85202065, 85209280, 85787623, 92303166, 92308616, 92309093, 94569017, 103389223, 104308418, 117872960, 121363547, 124659167, 124750234, 124881422, 125359355, 126657738, 126665920, 127958258, 131844541, 134338221, 135021034, 135610875, 135650978, 135698196, 137206250, 142058420, 144207133
SuperDrug ATC ID
R03AC12
SuperDrug CAS ID
cas=089365504
Target and Pathway
Target(s) Beta-2 adrenergic receptor Target Info Agonist [536966]
KEGG Pathway Calcium signaling pathway
cGMP-PKG signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Endocytosis
Adrenergic signaling in cardiomyocytes
Salivary secretion
NetPath Pathway TCR Signaling Pathway
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Beta2 adrenergic receptor signaling pathway
Pathway Interaction Database Arf6 trafficking events
Arf6 signaling events
Reactome Adrenoceptors
G alpha (s) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
GPCRs, Class A Rhodopsin-like
Vitamin D Receptor Pathway
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 536361Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. Epub 2007 Feb 20.
Ref 540957(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 559).
Ref 536966Pharmacogenetic tests in asthma therapy. Clin Lab Med. 2008 Dec;28(4):645-65.

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