Drug Information

Drug General Information
Drug ID
D0GA0A
Former ID
DAP001284
Drug Name
Interferon alfacon-1
Synonyms
Advaferon; Infergen; Advaferon (TN); Infergen (TN); Interferon alfacon-1 (genetical recombination); Interferon alfacon-1 (USAN/INN); Interferon alfacon-1 (genetical recombination) (JAN)
Indication Hairy cell leukemia; HCV infection [ICD9: 202.4, 070.4, 070.5, 070.70; ICD10:C91.4, B17.1, B18.2] Approved [536361], [551871]
Therapeutic Class
Anticancer Agents
Formula
C860H1353N227O255S9
CAS Number
CAS 118390-30-0
PubChem Substance ID
47205817
SuperDrug ATC ID
L03AB09; S01AD05
Target and Pathway
Target(s) Interferon-alpha/beta receptor Target Info Binder [537155]
KEGG Pathway Cytokine-cytokine receptor interaction
PI3K-Akt signaling pathway
Osteoclast differentiation
Toll-like receptor signaling pathway
Jak-STAT signaling pathway
Natural killer cell mediated cytotoxicity
Hepatitis C
Hepatitis B
Measles
Influenza A
Herpes simplex infection
Reactome Interferon alpha/beta signaling
Regulation of IFNA signaling
WikiPathways Toll-like receptor signaling pathway
Interferon type I signaling pathways
Interferon alpha/beta signaling
Regulation of toll-like receptor signaling pathway
Osteoclast Signaling
References
Ref 536361Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. Epub 2007 Feb 20.
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 537155Retreating chronic hepatitis C with daily interferon alfacon-1/ribavirin after nonresponse to pegylated interferon/ribavirin: DIRECT results. Hepatology. 2009 Jun;49(6):1838-46.

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