Drug Information

Drug General Information
Drug ID
D0J7XL
Former ID
DAP001327
Drug Name
Gramicidin D
Synonyms
Gramicidins; Gramoderm; Gramacidine S; Gramicidin C; Gramicidin Dubos; Gramicidin J; Gramicidin K; Gramicidin P; Gramicidin S; Gramicidin S [INN]; Gramicidina D; Gramicidina S; Gramicidinum S; Neosporin Ophthalmic Solution; Gramicin S 1; Gramacidine S [INN-French]; Gramicidin A(1); Gramicidin [INN:BAN]; Gramicidina S [INN-Spanish]; Gramicidina [INN-Spanish]; Gramicidine [INN-French]; Gramicidinum S [INN-Latin]; Gramicidinum [INN-Latin]; Gramicin S-A; Cyclo(L-valyl-L-ornithyl-L-leucyl-D-phenylalanyl-L-prolyl-L-valyl-L-ornithyl-L-leucyl-D-phenylalanyl-L-prolyl); 1,10-anhydro(L-leucyl-D-phenylalanyl-L-prolyl-L-valyl-L-ornithyl-L-leucyl-D-phenylalanyl-L-prolyl-L-valyl-L-ornithine)
Drug Type
Small molecular drug
Indication Bacterial infections [ICD9: 001-009, 010-018, 020-027, 030-041, 080-088, 090-099, 100-104; ICD10:A00-B99] Approved [550737]
Therapeutic Class
Antibiotics
Structure
Download
2D MOL

3D MOL
Formula
C60H92N12O10
Canonical SMILES
CC(C)CC1C(=O)NC(C(=O)N2CCCC2C(=O)NC(C(=O)NC(C(=O)NC(C(=<br />O)NC(C(=O)N3CCCC3C(=O)NC(C(=O)NC(C(=O)N1)CCCN)C(C)C)CC4<br />=CC=CC=C4)CC(C)C)CCCN)C(C)C)CC5=CC=CC=C5
InChI
1S/C60H92N12O10/c1-35(2)31-43-53(75)67-45(33-39-19-11-9-12-20-39)59(81)71-29-17-25-47(71)55(77)70-50(38(7)8)58(80)64-42(24-16-28-62)52(74)66-44(32-36(3)4)54(76)68-46(34-40-21-13-10-14-22-40)60(82)72-30-18-26-48(72)56(78)69-49(37(5)6)57(79)63-41(23-15-27-61)51(73)65-43/h9-14,19-22,35-38,41-50H,15-18,23-34,61-62H2,1-8H3,(H,63,79)(H,64,80)(H,65,73)(H,66,74)(H,67,75)(H,68,76)(H,69,78)(H,70,77)/t41-,42-,43-,44-,45+,46+,47-,48-,49-,50-/m0/s1
InChIKey
IUAYMJGZBVDSGL-XNNAEKOYSA-N
CAS Number
CAS 1405-97-6
PubChem Compound ID
73357
PubChem Substance ID
13398, 597753, 8195691, 14792521, 15040589, 24434783, 43129321, 49974134, 49974145, 56437676, 57319065, 79046679, 103504321, 104355075, 117366157, 125003439, 135031619, 137131341, 144205096, 162224784, 164810729, 174006635, 179293374, 180371194, 198935002, 226502912, 242587253
SuperDrug ATC ID
R02AB30
Target and Pathway
Target(s) Dihydropteroate synthetase Target Info Binder [535268]
References
Ref 550737Drug information of Gramicidin D, 2008. eduDrugs.
Ref 535268Structures of gramicidins A, B, and C incorporated into sodium dodecyl sulfate micelles. Biochemistry. 2001 Oct 2;40(39):11676-86.

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