Drug Information

Drug General Information
Drug ID
D02DGU
Former ID
DAP001221
Drug Name
Tretinoin
Synonyms
ATRA; Aberel; Aberela; Acnavit; Airol; Aknefug; Aknoten; Alitretinoin; Atragen; Atralin; Avitoin; Betarretin; Dermairol; Effederm; Eudyna; Lsotretinoin; Nexret; Panretyn; REA; Renova; Retacnyl; Retinoate; Retinova; Solage; TRETINON; Tretinoina; Tretinoine; Tretinoino; Tretinoinum; Vesanoid; Vesnaroid; Vitinoin; Aberela [Norway]; Accutane Roche; Acnavit [Denmark]; All Trans Retinoic Acid; Avita Gel; Avitoin [Norway]; Beta all trans Retinoic Acid; Cordes VAS [Germany]; Cordes vas; Effederm [France]; Isotretinoin Retinoicacid; Panretin Gel; Retin A; Retinoic acid; Retionic acid; Trans Retinoic Acid; Tretin M; Tretinoin Potassium Salt; Tretinoin Sodium Salt; Tretinoin Zinc Salt; Tretinoin liposome; Vitamin A acid; AGN100335; AGN 192013; ALRT 1057; BAL4079; LGD 100057; R 2625; [3H]Retinoic acid; A-Vitaminsyre; A-Vitaminsyre [Denmark]; AT-RA; Aberela (TN); Acid, Retinoic; Acid, Vitamin A; All trans-Retinoic acid; All-trans Retinoic Acid; Alltrans-retinoic acid; Atra-IV; Avita (TN); B-Retinoic acid; BML2-E05; Beta-Ra; Beta-Retinoic acid; Epi-aberel; Potassium Salt, Tretinoin; RETINOIC ACID, ALL TRANS; Renova (TN); Retin A (TN); Retin-A; Retin-A Micro; Retisol-A; Ro 1-5488; Salt, Tretinoin Potassium; Salt, Tretinoin Sodium; Salt, Tretinoin Zinc; Sodium Salt, Tretinoin; Stieva-A; Stieva-a Forte; Trans-Retinoicacid; Tretinoin (TN); Tretinoina [INN-Spanish]; Tretinoine [INN-French]; Tretinoino [INN-Spanish]; Tretinoinum [INN-Latin]; Tri-Luma; Vesanoid (TN); Zinc Salt, Tretinoin; A-Acido (Argentina); Acid A Vit (Belgium, Netherlands); Acid, trans-Retinoic; Acide retinoique (French) (DSL); All-trans-Retinoic acid; All-trans-Tretinoin; All-trans-Vitamin A acid; All-trans-Vitamin A1 acid; PDT-002-002; Retin-A (TN); Stieva-A (TN); Tretinoin 0.1% cream or placebo; Tretinoin [USAN:INN:BAN]; Tretinoin/All-Trans Retinoic Acid; Tretinoine (French) (EINECS); Acid, all-trans-Retinoic; All-(E)-Retinoic acid; All-trans-b-Retinoic acid; All-trans-beta-Retinoic acid; Beta-all-trans-Retinoic acid; Tretinoin (JAN/USP/INN); Acid, beta-all-trans-Retinoic; Retinoic acid, all-trans-(8CI); Vesanoid, Airol, Renova, Atralin, Retin-A, Avita, Tretinoin; 15-Apo-beta-caroten-15-oic acid; 3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic acid; 9(Z)-Retinoic acid; 9-cis-RA
Drug Type
Small molecular drug
Indication Acne vulgaris [ICD9: 706.1; ICD10:L70.0] Approved [536361], [539710]
Acute promyelocytic leukemia [ICD9: 205; ICD10:C92.4] Phase 2 [525348], [539710]
Therapeutic Class
Keratolytic Agents
Company
Roche Pharmaceuticals
Structure
Download
2D MOL

3D MOL
Formula
C20H28O2
InChI
InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8+,16-14+
InChIKey
SHGAZHPCJJPHSC-YCNIQYBTSA-N
CAS Number
CAS 302-79-4
PubChem Compound ID
444795
PubChem Substance ID
4038, 416403, 596063, 830710, 838467, 841067, 855632, 3138737, 7847162, 7890244, 7980826, 8143163, 8149916, 10299585, 10321438, 11528311, 12014646, 14825303, 14849563, 17405617, 24278674, 24702082, 26612256, 26680099, 26703748, 26716947, 26746936, 26746937, 26759442, 29214999, 31294611, 36887697, 46392576, 46487923, 47216527, 47959456, 47959457, 48110185, 48110186, 48184725, 48184726, 48184727, 48184728, 48258941, 48414424, 48483920, 49698408, 50103969, 50103970, 50126361
ChEBI ID
ChEBI:15367
SuperDrug ATC ID
D10AD01; L01XX14
SuperDrug CAS ID
cas=000302794
Target and Pathway
Target(s) Retinoic acid receptor Target Info Binder [535273]
References
Ref 525348Chromosomal translocation t(15;17) in human acute promyelocytic leukemia fuses RAR alpha with a novel putative transcription factor, PML. Cell. 1991 Aug 23;66(4):663-74.
Ref 536361Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. Epub 2007 Feb 20.
Ref 539710(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2644).
Ref 535273Retinoids--which dermatological indications will benefit in the near future? Skin Pharmacol Appl Skin Physiol. 2001 Sep-Oct;14(5):303-15.

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