Drug General Information
Drug ID	D05HCO
Former ID	DIB015294
Drug Name	1954U89
Indication	Solid tumours [ICD9: 140-199, 210-229; ICD10:C00-D48]		Preclinical	[534414]
Company	Glaxo Wellcome plc
Structure		Download 2D MOL 3D MOL
Canonical SMILES	c12c(n(c(c2)C)C(CC)CC)ccc2c1c(nc(n2)N)N
CAS Number	CAS 150057-49-1
Target and Pathway
Target(s)	DHFR	Target Info	Modulator	[534414]
KEGG Pathway	One carbon pool by folate
	Folate biosynthesis
	Metabolic pathways
PANTHER Pathway	Tetrahydrofolate biosynthesis
	Formyltetrahydroformate biosynthesis
Pathway Interaction Database	E2F transcription factor network
PathWhiz Pathway	Folate Metabolism
	Pterine Biosynthesis
Reactome	E2F mediated regulation of DNA replication
	Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
	Metabolism of folate and pterines
	G1/S-Specific Transcription
WikiPathways	Nucleotide Metabolism
	Trans-sulfuration and one carbon metabolism
	Retinoblastoma (RB) in Cancer
	One Carbon Metabolism
	Metabolism of water-soluble vitamins and cofactors
	Metabolism of nitric oxide
	Folate Metabolism
	Fluoropyrimidine Activity
References
Ref 534414	The pharmacokinetics of 1954U89, 1,3-diamino-7-(1-ethylpropyl)-8-methyl-7H-pyrrolo-(3,2-f)quinazoline, in dogs and rats after intravenous and oral administration. Biopharm Drug Dispos. 1997 Jul;18(5):433-42.
Ref 534414	The pharmacokinetics of 1954U89, 1,3-diamino-7-(1-ethylpropyl)-8-methyl-7H-pyrrolo-(3,2-f)quinazoline, in dogs and rats after intravenous and oral administration. Biopharm Drug Dispos. 1997 Jul;18(5):433-42.

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