Drug General Information
Drug ID	D0R1DP
Former ID	DIB012853
Drug Name	A-74283
Indication	Hypertension [ICD9: 401; ICD10:I10-I16]		Terminated	[545136]
Company	Abbott Laboratories
Structure		Download 2D MOL 3D MOL
Canonical SMILES	N1(C(=O)C2C(C1=O)C1C3C(C2C=C1)C=C3)CCCCN1C[C@H]2c3c(CC[<br />C@@H]2C1)cccc3OC.Cl
CAS Number	CAS 202754-51-6
Target and Pathway
Target(s)	5-hydroxytryptamine 1A receptor	Target Info	Agonist	[534558]
KEGG Pathway	cAMP signaling pathway
	Neuroactive ligand-receptor interaction
	Serotonergic synapse
PANTHER Pathway	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
	5HT1 type receptor mediated signaling pathway
Reactome	Serotonin receptors
	G alpha (i) signalling events
WikiPathways	Serotonin HTR1 Group and FOS Pathway
	SIDS Susceptibility Pathways
	Monoamine GPCRs
	GPCRs, Class A Rhodopsin-like
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 545136	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002258)
Ref 534558	Cardiovascular activity of A-74283, a 5-hydroxytryptamine 1A agent, in the spontaneously hypertensive rat. Pharmacology. 1998 Jan;56(1):17-29.

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