Drug Information

Drug General Information
Drug ID
D07JLM
Former ID
DIB007569
Drug Name
Alagebrium chloride
Synonyms
PTB; Tetrazolium chloride; ALT-711; ALT-766; N-phenacylthiazolium bromide; Advanced glycosylation end product (AGE)breakers, Alteon; Advanced glycosylation end product (AGE) breakers, Synvista
Drug Type
Small molecular drug
Indication Hypotension [ICD9: 458, 796.3; ICD10:I95] Phase 2/3 [523591]
Company
Synvista Therapeutics Inc
Structure
Download
2D MOL

3D MOL
Formula
C13H14ClNOS
Canonical SMILES
[n+]1(c(c(sc1)C)C)CC(=O)c1ccccc1.[Cl-]
PubChem Compound ID
216306
Target and Pathway
Target(s) Advanced glycosylation end product-specific receptor Target Info Breaker [530684], [531941]
Pathway Interaction Database amb2 Integrin signaling
Reactome RIP-mediated NFkB activation via ZBP1
DEx/H-box helicases activate type I IFN and inflammatory cytokines production
TAK1 activates NFkB by phosphorylation and activation of IKKs complex
Advanced glycosylation endproduct receptor signaling
TRAF6 mediated NF-kB activation
WikiPathways NRF2 pathway
Nuclear Receptors Meta-Pathway
Cytosolic sensors of pathogen-associated DNA
TAK1 activates NFkB by phosphorylation and activation of IKKs complex
AGE/RAGE pathway
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
Advanced glycosylation endproduct receptor signaling
References
Ref 523591ClinicalTrials.gov (NCT01417663) Effects of Exercise Training and AGE-crosslink Breaker on Cardiovascular Structure and Function. U.S. National Institutes of Health.
Ref 530684Effect of the age cross-link breaker alagebrium on anterior segment physiology, morphology, and ocular age and rage. Trans Am Ophthalmol Soc. 2009 Dec;107:146-58.
Ref 531941Alagebrium reduces glomerular fibrogenesis and inflammation beyond preventing RAGE activation in diabetic apolipoprotein E knockout mice. Diabetes. 2012 Aug;61(8):2105-13.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.