Drug General Information
Drug ID
D0E8CZ
Former ID
DCL000695
Drug Name
Amibegron
Synonyms
SR 58611; Amibegron (USAN/INN); Ethyl 2-[[(7S)-7-[[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino]-5,6,7,8-tetrahydronaphthalen-2-yl]oxy]acetate
Drug Type
Small molecular drug
Indication Major depressive disorder; Obesity; Type 2 diabetes [ICD9: 250, 250.00, 250.02, 278, 296, 296.2, 296.3; ICD10:E08-E13, E11, E66, F30-F39, F32, F33] Preclinical [536580], [541023]
Major depressive disorder; Severe mood disorders [ICD9: 296, 296.2, 296.3; ICD10:F30-F39, F32, F33] Discontinued in Phase 3 [536580], [541023]
Company
Sanofi-Aventis; Eli Lilly
Structure
Download
2D MOL

3D MOL

Formula
C22H26ClNO4
InChI
InChI=1S/C22H26ClNO4/c1-2-27-22(26)14-28-20-9-7-15-6-8-19(11-17(15)12-20)24-13-21(25)16-4-3-5-18(23)10-16/h3-5,7,9-10,12,19,21,24-25H,2,6,8,11,13-14H2,1H3/t19-,21-/m0/s1
InChIKey
RDJQCOBTKKAQAH-FPOVZHCZSA-N
CAS Number
CAS 121524-08-1
PubChem Compound ID
PubChem Substance ID
Target and Pathway
Target(s) Beta-3 adrenergic receptor Target Info Agonist [536580]
KEGG Pathway Calcium signaling pathway
cGMP-PKG signaling pathway
Neuroactive ligand-receptor interaction
Endocytosis
Salivary secretion
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Beta3 adrenergic receptor signaling pathway
Reactome Adrenoceptors
G alpha (s) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 536580Novel drugs and therapeutic targets for severe mood disorders. Neuropsychopharmacology. 2008 Aug;33(9):2080-92. Epub 2008 Jan 2.
Ref 541023(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 568).
Ref 536580Novel drugs and therapeutic targets for severe mood disorders. Neuropsychopharmacology. 2008 Aug;33(9):2080-92. Epub 2008 Jan 2.

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