Drug Information

Drug General Information
Drug ID
D0Z6AX
Former ID
DIB003686
Drug Name
BAY-27-9955
Synonyms
Glucagon antagonists, Bayer
Drug Type
Small molecular drug
Indication Type 2 diabetes [ICD9: 250; ICD10:E11] Discontinued in Phase 1 [540430], [547099]
Company
Bayer AG
Structure
Download
2D MOL

3D MOL
Formula
C23H31FO
InChI
InChI=1S/C23H31FO/c1-7-8-19-20(14(2)3)13-21(15(4)5)22(16(6)25)23(19)17-9-11-18(24)12-10-17/h9-16,25H,7-8H2,1-6H3
InChIKey
VDTWKXAPIQBOMO-UHFFFAOYSA-N
PubChem Compound ID
5311277
PubChem Substance ID
7979920, 11056401, 16280413, 39340976, 50605898, 114155727, 129460525, 136942885, 136964662, 140941003, 142377617, 172649679, 178100480, 198943480, 226480344
Target and Pathway
Target(s) Glucagon receptor Target Info Antagonist [526203]
KEGG Pathway Neuroactive ligand-receptor interaction
Glucagon signaling pathway
Reactome Glucagon signaling in metabolic regulation
G alpha (q) signalling events
G alpha (s) signalling events
Glucagon-type ligand receptors
WikiPathways GPCRs, Class B Secretin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Integration of energy metabolism
GPCR ligand binding
GPCR downstream signaling
References
Ref 540430(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3491).
Ref 547099Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800013061)
Ref 526203Effects of a novel glucagon receptor antagonist (Bay 27-9955) on glucagon-stimulated glucose production in humans. Diabetologia. 2001 Nov;44(11):2018-24.

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