TTD | Drug: D07DGM

Drug General Information
Drug ID	D07DGM
Former ID	DIB008555
Drug Name	BQ-518
Drug Type	Small molecular drug
Indication	Hypertension [ICD9: 401; ICD10:I10-I16]		Terminated	[546191]
Company	MSD Japan
Structure		Download 2D MOL 3D MOL
Formula	C32H38N6O7S
Canonical SMILES	N12C(=O)[C@H](NC(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=<br />O)[C@@H]1CCC2)c1sccc1)CC(C)C)Cc1c[nH]c2c1cccc2)CC(=O)O
CAS Number	CAS 136554-29-5
PubChem Compound ID	443291
Target and Pathway
Target(s)	Endothelin-1 receptor	Target Info	Modulator	[533587]
KEGG Pathway	Calcium signaling pathway
	cGMP-PKG signaling pathway
	cAMP signaling pathway
	Neuroactive ligand-receptor interaction
	Vascular smooth muscle contraction
	Renin secretion
	Pathways in cancer
NetPath Pathway	IL4 Signaling Pathway
PANTHER Pathway	Endothelin signaling pathway
Pathway Interaction Database	Endothelins
Pathway Interaction Database	EGFR-dependent Endothelin signaling events
Reactome	Peptide ligand-binding receptors
Reactome	G alpha (q) signalling events
WikiPathways	Prostaglandin Synthesis and Regulation
	GPCRs, Class A Rhodopsin-like
	Gastrin-CREB signalling pathway via PKC and MAPK
	Peptide GPCRs
	Endothelin Pathways
	GPCR ligand binding
	GPCR downstream signaling
	GPCRs, Other
References
Ref 546191	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800006825)
Ref 533587	Structure-activity relationships of cyclic pentapeptide endothelin A receptor antagonists. J Med Chem. 1995 Oct 13;38(21):4309-24.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.

Drug Information