Drug Information

Drug General Information
Drug ID
D04DZE
Former ID
DNC000345
Drug Name
BRL 26830A
Drug Type
Small molecular drug
Indication Obesity [ICD9: 278; ICD10:E66] Terminated [544638]
Structure
Download
2D MOL

3D MOL
Formula
C24H29NO6
Canonical SMILES
CC(CC1=CC=C(C=C1)C(=O)OC)NCC(C2=CC=CC=C2)O.CC(=O)C=CC(=<br />O)O
InChI
1S/C19H23NO3.C5H6O3/c1-14(20-13-18(21)16-6-4-3-5-7-16)12-15-8-10-17(11-9-15)19(22)23-2;1-4(6)2-3-5(7)8/h3-11,14,18,20-21H,12-13H2,1-2H3;2-3H,1H3,(H,7,8)/b;3-2+/t14-,18+;/m0./s1
InChIKey
OIZISCUUSLPUEN-LMORPYAASA-N
CAS Number
CAS 87857-42-9
PubChem Compound ID
6438331
PubChem Substance ID
43031341, 50070357, 53787446, 57367993, 75730432, 114555848, 134339791, 135078254
Target and Pathway
Target(s) Beta-3 adrenergic receptor Target Info Agonist [536256]
KEGG Pathway Calcium signaling pathway
cGMP-PKG signaling pathway
Neuroactive ligand-receptor interaction
Endocytosis
Salivary secretion
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Beta3 adrenergic receptor signaling pathway
Reactome Adrenoceptors
G alpha (s) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 544638Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000393)
Ref 536256Anti-obesity and anti-diabetic actions of a beta 3-adrenoceptor agonist, BRL 26830A, in yellow KK mice. Endocrinol Jpn. 1991 Aug;38(4):397-403.

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