Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0R7YY
|
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| Former ID |
DIB015427
|
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| Drug Name |
Darusentan
|
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| Synonyms |
Endothelin antagonist, BASF; HMR-4005; LU-127043; LU-135252
|
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| Drug Type |
Small molecular drug
|
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| Company |
Gilead Sciences; Knoll GmbH
|
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| Structure |
|
Download2D MOL |
|||
| Formula |
C22H22N2O6
|
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| InChI |
InChI=1S/C22H22N2O6/c1-27-17-14-18(28-2)24-21(23-17)30-19(20(25)26)22(29-3,15-10-6-4-7-11-15)16-12-8-5-9-13-16/h4-14,19H,1-3H3,(H,25,26)/t19-/m1/s1
|
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| InChIKey |
FEJVSJIALLTFRP-LJQANCHMSA-N
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| PubChem Compound ID | |||||
| PubChem Substance ID |
7979815, 10258564, 12015030, 14904202, 14928792, 33500713, 49881054, 53788749, 57395363, 76344031, 103191671, 104003423, 104426232, 118855309, 126681579, 127834770, 135154690, 137249396, 139988415, 152133971, 163884607, 170466416, 175426886, 178100494, 179150062, 187071946, 198954978, 198979503, 198991928, 223661592, 227075098
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| Target and Pathway | |||||
| Target(s) | Endothelin-1 receptor | Target Info | Antagonist | [528154] | |
| NetPath Pathway | IL4 Signaling Pathway | ||||
| PANTHER Pathway | Endothelin signaling pathway | ||||
| Pathway Interaction Database | Endothelins | ||||
| EGFR-dependent Endothelin signaling events | |||||
| References | |||||
| Ref 521903 | ClinicalTrials.gov (NCT00389779) DORADO-AC - Optimized Doses of Darusentan as Compared to an Active Control in Resistant Hypertension. U.S. National Institutes of Health. | ||||
| Ref 540446 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3508). | ||||
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