Drug Information

Drug General Information
Drug ID
D0B1MJ
Former ID
DIB009539
Drug Name
Dexniguldipine
Synonyms
Dexniguldipine hydrochloride; BY-935; B-8509-035; B-859-35
Drug Type
Small molecular drug
Indication Cancer [ICD9: 140-229; ICD10:C00-C96] Discontinued in Phase 2 [467869], [545229]
Company
ALTANA Pharma AG
Structure
Download
2D MOL

3D MOL
Formula
C36H39N3O6
InChI
InChI=1S/C36H39N3O6/c1-25-31(34(40)44-3)33(27-12-10-17-30(24-27)39(42)43)32(26(2)37-25)35(41)45-23-11-20-38-21-18-36(19-22-38,28-13-6-4-7-14-28)29-15-8-5-9-16-29/h4-10,12-17,24,33,37H,11,18-23H2,1-3H3/t33-/m1/s1
InChIKey
SVJMLYUFVDMUHP-MGBGTMOVSA-N
PubChem Compound ID
6918097
PubChem Substance ID
14789507, 14911981, 23950802, 43529492, 47434813, 48179674, 80372165, 103942847, 114787431, 134341343, 135183324, 135650907, 139282995, 160690555, 198939748, 225066780, 227012617
Target and Pathway
Target(s) Multidrug resistance protein 3 Target Info Modulator [533783]
KEGG Pathway ABC transporters
Bile secretion
Reactome PPARA activates gene expression
ABC-family proteins mediated transport
WikiPathways Nuclear Receptors in Lipid Metabolism and Toxicity
Farnesoid X Receptor Pathway
Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
References
Ref 467869(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 463).
Ref 545229Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002528)
Ref 533783Mechanism of action of dexniguldipine-HCl (B8509-035), a new potent modulator of multidrug resistance. Biochem Pharmacol. 1995 Mar 1;49(5):603-9.

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