Drug Information
Drug General Information | |||||
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Drug ID |
D0RJ6R
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Former ID |
DIB003815
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Drug Name |
Du-123015
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Synonyms |
Benzopyran piperazine derivative (5HT modulator, neurological disorders), Solvay
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Indication | Anxiety disorder [ICD9: 300, 311; ICD10:F32, F40-F42] | Terminated | [1] | ||
Company |
Solvay SA
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Structure |
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Download2D MOL |
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Canonical SMILES |
c1(=O)oc2c(cc1N)cccc2N1CCNCC1.Cl.O
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Target and Pathway | |||||
Target(s) | 5-hydroxytryptamine 1A receptor | Target Info | Modulator | [2] | |
KEGG Pathway | cAMP signaling pathway | ||||
Neuroactive ligand-receptor interaction | |||||
Serotonergic synapse | |||||
PANTHER Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | ||||
5HT1 type receptor mediated signaling pathway | |||||
Reactome | Serotonin receptors | ||||
G alpha (i) signalling events | |||||
WikiPathways | Serotonin HTR1 Group and FOS Pathway | ||||
SIDS Susceptibility Pathways | |||||
Monoamine GPCRs | |||||
GPCRs, Class A Rhodopsin-like | |||||
GPCR ligand binding | |||||
GPCR downstream signaling | |||||
References | |||||
REF 1 | Neither in vivo MRI nor behavioural assessment indicate therapeutic efficacy for a novel 5HT1A agonist in rat models of ischaemic stroke. BMC Neuroscience 2009, 10:82. | ||||
REF 2 | Neither in vivo MRI nor behavioural assessment indicate therapeutic efficacy for a novel 5HT1A agonist in rat models of ischaemic stroke. BMC Neuroscience 2009, 10:82. | ||||
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