Drug General Information
Drug ID	D0BN4Y
Former ID	DIB014567
Drug Name	Ebalzotan
Synonyms	NAE-086
Drug Type	Small molecular drug
Indication	Anxiety disorder [ICD9: 300, 311; ICD10:F32, F40-F42]		Discontinued in Phase 1	[546211]
Company	Astra AB
Structure		Download 2D MOL 3D MOL
Formula	C19H30N2O2
Canonical SMILES	C(=O)(c1c2C[C@@H](N(C(C)C)CCC)COc2ccc1)NC(C)C
CAS Number	CAS 149494-37-1
PubChem Compound ID	9797080
Target and Pathway
Target(s)	5-hydroxytryptamine 1A receptor	Target Info	Agonist	[526199]
KEGG Pathway	cAMP signaling pathway
	Neuroactive ligand-receptor interaction
	Serotonergic synapse
PANTHER Pathway	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
	5HT1 type receptor mediated signaling pathway
Reactome	Serotonin receptors
	G alpha (i) signalling events
WikiPathways	Serotonin HTR1 Group and FOS Pathway
	SIDS Susceptibility Pathways
	Monoamine GPCRs
	GPCRs, Class A Rhodopsin-like
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 546211	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800006909)
Ref 526199	The pharmacological profile of (R)-3,4-dihydro-N-isopropyl-3-(N-isopropyl-N-propylamino)-2H-1-benzopyran-5-carboxamide, a selective 5-hydroxytryptamine(1A) receptor agonist. J Pharmacol Exp Ther. 2001 Dec;299(3):883-93.

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