Drug General Information
Drug ID	D00CIF
Former ID	DIB003352
Drug Name	EMD-503982
Synonyms	EMD-495235; Factor Xa inhibitors, Merck KGaA
Indication	Thrombosis [ICD9: 437.6, 453, 671.5, 671.9; ICD10:I80-I82]		Discontinued in Phase 1	[548116]
Company	Merck KGaA
Structure		Download 2D MOL 3D MOL
Canonical SMILES	c1(ccc(cc1)NC(=O)N1[C@H](C[C@H](C1)O)C(=O)Nc1ccc(cc1)N1<br />C(=O)COCC1)Cl
Target and Pathway
Target(s)	Coagulation factor Xa	Target Info	Inhibitor	[531405], [531982]
KEGG Pathway	Complement and coagulation cascades
PANTHER Pathway	Blood coagulation
Pathway Interaction Database	Beta2 integrin cell surface interactions
PathWhiz Pathway	Coagulation
Reactome	Extrinsic Pathway of Fibrin Clot Formation
	Intrinsic Pathway of Fibrin Clot Formation
	Common Pathway of Fibrin Clot Formation
	Gamma-carboxylation of protein precursors
	Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus
	Removal of aminoterminal propeptides from gamma-carboxylated proteins
WikiPathways	Complement and Coagulation Cascades
	Human Complement System
	PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
	Blood Clotting Cascade
	Formation of Fibrin Clot (Clotting Cascade)
References
Ref 548116	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800022087)
Ref 531405	Venous thromboembolism in the patient with cancer: focus on burden of disease and benefits of thromboprophylaxis. Cancer. 2011 Apr 1;117(7):1334-49.
Ref 531982	Semuloparin for the prevention of venous thromboembolic events in cancer patients. Drugs Today (Barc). 2012 Jul;48(7):451-7.

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