Drug General Information
Drug ID	D0X2PQ
Former ID	DIB016647
Drug Name	IX207-887
Indication	Rheumatoid arthritis [ICD9: 710-719, 714; ICD10:M05-M06]		Discontinued in Phase 2	[545177]
Company	Sandoz AG
Structure		Download 2D MOL 3D MOL
Canonical SMILES	C\1(=C\C(=O)O)/c2c(C(=Cc3c1cccc3)OC)scc2
CAS Number	CAS 98320-39-9
Target and Pathway
Target(s)	Interleukin-1 alpha ligand	Target Info	Modulator	[532430]
KEGG Pathway	MAPK signaling pathway
	Cytokine-cytokine receptor interaction
	Apoptosis
	Osteoclast differentiation
	Hematopoietic cell lineage
	Non-alcoholic fatty liver disease (NAFLD)
	Type I diabetes mellitus
	Prion diseases
	Salmonella infection
	Pertussis
	Leishmaniasis
	Tuberculosis
	Measles
	Influenza A
	Inflammatory bowel disease (IBD)
	Rheumatoid arthritis
	Graft-versus-host disease
NetPath Pathway	IL5 Signaling Pathway
	IL1 Signaling Pathway
	TCR Signaling Pathway
PANTHER Pathway	Interleukin signaling pathway
Pathway Interaction Database	IL1-mediated signaling events
	Validated transcriptional targets of deltaNp63 isoforms
	a6b1 and a6b4 Integrin signaling
Reactome	Senescence-Associated Secretory Phenotype (SASP)
	Interleukin-1 signaling
	Interleukin-1 processing
WikiPathways	SIDS Susceptibility Pathways
	TCR Signaling Pathway
	Senescence and Autophagy in Cancer
	Cytokines and Inflammatory Response
	Hypertrophy Model
	MAPK Signaling Pathway
	FAS pathway and Stress induction of HSP regulation
	Hematopoietic Stem Cell Differentiation
	Structural Pathway of Interleukin 1 (IL-1)
	Spinal Cord Injury
	Allograft Rejection
	IL-1 signaling pathway
	Interleukin-1 signaling
References
Ref 545177	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002363)
Ref 532430	Inhibition of interleukin-1 release by IX 207-887. Agents Actions. 1990 Jun;30(3-4):350-62.

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