Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0SV7D
|
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| Former ID |
DNC004308
|
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| Drug Name |
LOTRAFIBAN
|
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| Drug Type |
Small molecular drug
|
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| Indication | Cardiovascular disorder [ICD10:I00-I99] | Discontinued in Phase 3 | [545754] | ||
| Structure |
|
Download2D MOL |
|||
| Formula |
C23H32N4O4
|
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| Canonical SMILES |
CN1CC2=C(C=CC(=C2)C(=O)N3CCC(CC3)C4CCNCC4)NC(C1=O)CC(=O<br />)O
|
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| InChI |
1S/C23H32N4O4/c1-26-14-18-12-17(2-3-19(18)25-20(23(26)31)13-21(28)29)22(30)27-10-6-16(7-11-27)15-4-8-24-9-5-15/h2-3,12,15-16,20,24-25H,4-11,13-14H2,1H3,(H,28,29)/t20-/m0/s1
|
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| InChIKey |
PYZOVVQJTLOHDG-FQEVSTJZSA-N
|
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | Glycoprotein IIb/IIIa receptor | Target Info | Modulator | ||
| Reactome | Platelet degranulation | ||||
| Elastic fibre formation | |||||
| PECAM1 interactions | |||||
| Molecules associated with elastic fibres | |||||
| Integrin cell surface interactions | |||||
| Syndecan interactions | |||||
| ECM proteoglycans | |||||
| Integrin alphaIIb beta3 signaling | |||||
| GRB2:SOS provides linkage to MAPK signaling for Integrins | |||||
| p130Cas linkage to MAPK signaling for integrins | |||||
| VEGFA-VEGFR2 Pathway | |||||
| MAP2K and MAPK activation | |||||
| References | |||||
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