Drug General Information
Drug ID
D0K5HD
Former ID
DIB010036
Drug Name
LY-315902
Indication Type 2 diabetes [ICD9: 250; ICD10:E11] Discontinued in Phase 1 [546563]
Company
Eli Lilly & Co
Structure
Download
2D MOL

3D MOL

Canonical SMILES
[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C<br />(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)NCC<br />(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C<br />@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=<br />O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=<br />O)NCC(=O)O)CCCNC(=N)N)CCCCNC(=O)CCCCCCC)C(C)C)CC(C)C)Cc<br />1c[nH]c2c1cccc2)C)[C@H](CC)C)Cc1ccccc1)CCC(=O)O)CCCNC(=<br />N)N)C)C)CCC(=O)N)CCC(=O)O)CC(C)C)Cc1ccc(cc1)O)CO)CO)C(C<br />)C)CC(=O)O)CO)(NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)CNC(=O)[<br />C@@H](NC(=O)[C@@H](NC(=O)CCc1[nH]cnc1)C)CCC(=O)O)[C@H](<br />O)C)Cc1ccccc1)[C@H](O)C
CAS Number
CAS 176435-10-2
Target and Pathway
Target(s) Glucagon-like peptide 1 receptor Target Info Modulator [526351]
KEGG Pathway cAMP signaling pathway
Neuroactive ligand-receptor interaction
Insulin secretion
Reactome Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
G alpha (s) signalling events
Glucagon-type ligand receptors
WikiPathways GPCRs, Class B Secretin-like
Integration of energy metabolism
GPCR ligand binding
GPCR downstream signaling
References
Ref 546563Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800008960)
Ref 526351Glucagon-like peptide-1 analogue LY315902: effect on intestinal motility and release of insulin and somatostatin. Regul Pept. 2002 Jun 15;106(1-3):89-95.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.