Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0T0GJ
|
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| Former ID |
DNC001507
|
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| Drug Name |
VX-497
|
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| Drug Type |
Small molecular drug
|
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| Indication | Hepatitis virus infection [ICD9: 573.3; ICD10:K75.9] | Discontinued in Phase 2 | [1] | ||
| Structure |
|
Download2D MOL |
|||
| Formula |
C23H24N4O6
|
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| Canonical SMILES |
COC1=C(C=CC(=C1)NC(=O)NC2=CC=CC(=C2)CNC(=O)OC3CCOC3)C4=<br />CN=CO4
|
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| InChI |
1S/C23H24N4O6/c1-30-20-10-17(5-6-19(20)21-12-24-14-32-21)27-22(28)26-16-4-2-3-15(9-16)11-25-23(29)33-18-7-8-31-13-18/h2-6,9-10,12,14,18H,7-8,11,13H2,1H3,(H,25,29)(H2,26,27,28)/t18-/m0/s1
|
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| InChIKey |
JBPUGFODGPKTDW-SFHVURJKSA-N
|
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| CAS Number |
CAS 198821-22-6
|
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| PubChem Compound ID | |||||
| PubChem Substance ID |
640687, 10251736, 12015083, 14784233, 14857722, 46229554, 47206686, 52470262, 57347884, 103261008, 103998789, 104435748, 128251684, 134223085, 134338650, 134340678, 135110565, 137237685, 137267687, 141966212, 163306660, 175426334, 175426871, 179150134, 184528635, 198954413, 210275043, 210280681, 224157104, 226666702, 242060097, 252479539
|
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| Target and Pathway | |||||
| Target(s) | Inosine-5'-monophosphate dehydrogenase | Target Info | Inhibitor | [2] | |
| References | |||||
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800008158) | ||||
| REF 2 | VX-497: a novel, selective IMPDH inhibitor and immunosuppressive agent. J Pharm Sci. 2001 May;90(5):625-37. | ||||
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