Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0U9IQ
|
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| Former ID |
DCL001077
|
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| Drug Name |
PF-477736
|
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| Drug Type |
Small molecular drug
|
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| Company |
Pfizer
|
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| Structure |
|
Download2D MOL |
|||
| Formula |
C22H25N7O2
|
||||
| InChI |
InChI=1S/C22H25N7O2/c1-29-11-13(9-25-29)20-16-10-24-28-21(30)15-7-14(8-17(27-20)18(15)16)26-22(31)19(23)12-5-3-2-4-6-12/h7-12,19,24H,2-6,23H2,1H3,(H,26,31)(H,28,30)/t19-/m1/s1
|
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| InChIKey |
YFNWWNRZJGMDBR-LJQANCHMSA-N
|
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| PubChem Compound ID | |||||
| PubChem Substance ID |
26738683, 134339473, 135267502, 135653612, 136920310, 137275976, 142910601, 152258067, 152344328, 160646905, 162009842, 162011615, 162205240, 162249186, 172650635, 174007106, 177749453, 189614649, 198964618, 203090938, 223705255, 238593669, 241376902, 243967249, 251963197, 252157928, 252160096, 252450359, 252543444
|
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| Target and Pathway | |||||
| Target(s) | Serine/threonine-protein kinase Chk1 | Target Info | Inhibitor | [537564] | |
| Pathway Interaction Database | Fanconi anemia pathway | ||||
| p73 transcription factor network | |||||
| ATR signaling pathway | |||||
| Circadian rhythm pathway | |||||
| p53 pathway | |||||
| Reactome | Activation of ATR in response to replication stress | ||||
| Processing of DNA double-strand break ends | |||||
| Presynaptic phase of homologous DNA pairing and strand exchange | |||||
| G2/M DNA damage checkpoint | |||||
| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A | |||||
| Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex | |||||
| References | |||||
| Ref 542941 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8043). | ||||
| Ref 548144 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800022394) | ||||
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