Drug General Information |
Drug ID |
D09SLU
|
Former ID |
DIB014432
|
Drug Name |
LG-101280
|
Synonyms |
LG-101280; LSN-862; LY-WWW; LY-YYY; PPAR modulators, Ligand/Lilly
|
Indication |
Arteriosclerosis [ICD9: 440; ICD10:I70]
|
Discontinued in Phase 1 |
[1]
|
Company |
Ligand Pharmaceuticals Inc
|
Structure |
|
Download
2D MOL
3D MOL
|
Canonical SMILES |
c1(ccc(cc1CC)OCC[C@@H](C)Oc1c(cc(cc1)CC)c1ncccc1)CCC(=O<br />)O
|
Target and Pathway |
Target(s) |
Peroxisome proliferator activated receptor alpha |
Target Info |
Modulator |
[2]
|
KEGG Pathway
|
PPAR signaling pathway
|
cAMP signaling pathway
|
Adipocytokine signaling pathway
|
Glucagon signaling pathway
|
Non-alcoholic fatty liver disease (NAFLD)
|
Hepatitis C
|
Pathway Interaction Database
|
RXR and RAR heterodimerization with other nuclear receptor
|
Reactome
|
RORA activates gene expression
|
BMAL1:CLOCK,NPAS2 activates circadian gene expression
|
PPARA activates gene expression
|
YAP1- and WWTR1 (TAZ)-stimulated gene expression
|
Transcriptional activation of mitochondrial biogenesis
|
Activation of gene expression by SREBF (SREBP)
|
Transcriptional regulation of white adipocyte differentiation
|
Nuclear Receptor transcription pathway
|
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
|
Circadian Clock
|
WikiPathways
|
Nuclear Receptors in Lipid Metabolism and Toxicity
|
Nuclear Receptors Meta-Pathway
|
Estrogen Receptor Pathway
|
PPAR Alpha Pathway
|
Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
|
Transcriptional Regulation of White Adipocyte Differentiation
|
YAP1- and WWTR1 (TAZ)-stimulated gene expression
|
Activation of Gene Expression by SREBP (SREBF)
|
Adipogenesis
|
SREBF and miR33 in cholesterol and lipid homeostasis
|
Circadian Clock
|
Nuclear Receptors
|
References |
REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800014823) |
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REF 2 | A peroxisome proliferator-activated receptor alpha/gamma dual agonist with a unique in vitro profile and potent glucose and lipid effects in rodent models of type 2 diabetes and dyslipidemia. Mol Endocrinol. 2005 Jun;19(6):1593-605. Epub 2005 Apr 14. |