Drug General Information
Drug ID	D01SWK
Former ID	DIB016776
Drug Name	Rafabegron
Synonyms	AD-9677; AJ-9677; TAK-677
Drug Type	Small molecular drug
Indication	Type 2 diabetes [ICD9: 250; ICD10:E11]		Discontinued in Phase 2	[546607]
Company	Dainippon Pharmaceutical Co Ltd
Structure		Download 2D MOL 3D MOL
Formula	C21H23ClN2O4
Canonical SMILES	c12c(c(c[nH]2)C[C@H](NC[C@@H](c2cc(ccc2)Cl)O)C)cccc1OCC<br />(=O)O
CAS Number	CAS 244081-42-3
PubChem Compound ID	5493324
Target and Pathway
Target(s)	Beta-3 adrenergic receptor	Target Info	Modulator	[528534]
KEGG Pathway	Calcium signaling pathway
	cGMP-PKG signaling pathway
	Neuroactive ligand-receptor interaction
	Endocytosis
	Salivary secretion
PANTHER Pathway	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
	Beta3 adrenergic receptor signaling pathway
Reactome	Adrenoceptors
	G alpha (s) signalling events
WikiPathways	Monoamine GPCRs
	Calcium Regulation in the Cardiac Cell
	GPCRs, Class A Rhodopsin-like
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 546607	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800009164)
Ref 528534	Lack of an effect of a novel beta3-adrenoceptor agonist, TAK-677, on energy metabolism in obese individuals: a double-blind, placebo-controlled randomized study. J Clin Endocrinol Metab. 2007 Feb;92(2):527-31. Epub 2006 Nov 21.

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