Drug Information

Drug General Information
Drug ID
D08JAP
Former ID
DNC001228
Drug Name
Robalzotan
Drug Type
Small molecular drug
Indication Anxiety disorder [ICD9: 300, 311; ICD10:F32, F40-F42] Discontinued in Phase 2 [542212], [546103]
Structure
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2D MOL

3D MOL
Formula
C18H23FN2O2
InChI
InChI=1S/C18H23FN2O2/c19-16-8-7-14(18(20)22)15-9-13(10-23-17(15)16)21(11-3-1-4-11)12-5-2-6-12/h7-8,11-13H,1-6,9-10H2,(H2,20,22)/t13-/m1/s1
InChIKey
MQTUXRKNJYPMCG-CYBMUJFWSA-N
CAS Number
CAS 169758-66-1
PubChem Compound ID
3055171
PubChem Substance ID
10057422, 14826041, 14923725, 36120871, 50066221, 50554013, 57354004, 111625511, 124964078, 126522391, 128634387, 134340442, 135151729, 135650677, 137147743, 143228039, 162223589, 176224937, 198970138, 206245617, 215779892, 223554847, 226487455, 252216219
Target and Pathway
Target(s) 5-hydroxytryptamine 1A receptor Target Info Antagonist [535041]
KEGG Pathway cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT1 type receptor mediated signaling pathway
Reactome Serotonin receptors
G alpha (i) signalling events
WikiPathways Serotonin HTR1 Group and FOS Pathway
SIDS Susceptibility Pathways
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 542212(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 72).
Ref 546103Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800006370)
Ref 535041Use of PET and the radioligand [carbonyl-(11)C]WAY-100635 in psychotropic drug development. Nucl Med Biol. 2000 Jul;27(5):515-21.

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