TTD | Drug: D0G9FP

Drug General Information
Drug ID	D0G9FP
Former ID	DIB001850
Drug Name	Rofleponide
Synonyms	RPL; RPNS; Rofleponide palmitate; D-5522; Rofleponide 21-palmitate
Drug Type	Small molecular drug
Indication	Allergic rhinitis [ICD9: 472.0, 477, 995.3; ICD10:J00, J30, J31.0, T78.4]		Discontinued in Phase 2	[546294]
Company	AstraZeneca plc
Structure		Download 2D MOL 3D MOL
Formula	C25H34F2O6
Canonical SMILES	[C@@]12([C@@]3([C@H]([C@H]4[C@@]([C@@]5(C(=CC(=O)CC5)[C<br />@H](C4)F)C)([C@H](C3)O)F)C[C@H]1O[C@H](O2)CCC)C)C(=O)CO<br />C(=O)CCCCCCCCCCCCCCC
PubChem Compound ID	70018818
Target and Pathway
Target(s)	Steroid hormone receptor ERR1	Target Info	Modulator	[534346]
Reactome	PPARA activates gene expression
	Transcriptional activation of mitochondrial biogenesis
	Nuclear Receptor transcription pathway
WikiPathways	Mitochondrial Gene Expression
	Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
	Nuclear Receptors
References
Ref 546294	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800007303)
Ref 534346	Direct activation of GABAA receptors by loreclezole, an anticonvulsant drug with selectivity for the beta-subunit. Neuropharmacology. 1996;35(12):1753-60.

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Drug Information