Drug General Information
Drug ID	D08HDD
Former ID	DIB009195
Drug Name	RP-58802B
Drug Type	Small molecular drug
Indication	Asthma [ICD10:J45]		Terminated	[544951]
Company	Rhone-Poulenc SA
Structure		Download 2D MOL 3D MOL
Formula	C20H25N3O3
Canonical SMILES	n1cn(c2c1cccc2)CCC(NCC(c1cc(c(cc1)O)OC)O)C.Cl.Cl
CAS Number	CAS 88578-14-7
PubChem Compound ID	65665
Target and Pathway
Target(s)	Beta-2 adrenergic receptor	Target Info	Modulator	[526640]
KEGG Pathway	Calcium signaling pathway
	cGMP-PKG signaling pathway
	cAMP signaling pathway
	Neuroactive ligand-receptor interaction
	Endocytosis
	Adrenergic signaling in cardiomyocytes
	Salivary secretion
NetPath Pathway	TCR Signaling Pathway
PANTHER Pathway	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
	Beta2 adrenergic receptor signaling pathway
Pathway Interaction Database	Arf6 trafficking events
	Arf6 signaling events
Reactome	Adrenoceptors
	G alpha (s) signalling events
WikiPathways	Monoamine GPCRs
	Calcium Regulation in the Cardiac Cell
	GPCRs, Class A Rhodopsin-like
	Vitamin D Receptor Pathway
	GPCR ligand binding
	GPCR downstream signaling
	GPCRs, Other
References
Ref 544951	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001694)
Ref 526640	RP 58802B, a long-acting beta 2-adrenoceptor agonist: assessment of antiasthma activity in the guinea-pig in vivo. Pulm Pharmacol. 1992 Sep;5(3):203-12.

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