Drug Information

Drug General Information
Drug ID
D06HRY
Former ID
DNC003939
Drug Name
SNAP-5089
Drug Type
Small molecular drug
Indication Heart arrhythmia [ICD10:I47-I49] Terminated [468115], [546179]
Structure
Download
2D MOL

3D MOL
Formula
C36H40N4O5
InChI
InChI=1S/C36H40N4O5/c1-25-31(33(32(26(2)38-25)35(42)45-3)27-15-17-30(18-16-27)40(43)44)34(41)37-21-10-22-39-23-19-36(20-24-39,28-11-6-4-7-12-28)29-13-8-5-9-14-29/h4-9,11-18,33,38H,10,19-24H2,1-3H3,(H,37,41)/t33-/m1/s1
InChIKey
FIIXCJGBCCCOQQ-MGBGTMOVSA-N
PubChem Compound ID
5311437
PubChem Substance ID
7980617, 11056507, 16866201, 39341112, 75528589, 103445454, 114156094, 134342134, 135651060, 231023210
Target and Pathway
Target(s) Alpha-2B adrenergic receptor Target Info Inhibitor [525611]
Alpha-1A adrenergic receptor Target Info Inhibitor [533638]
Alpha-2C adrenergic receptor Target Info Inhibitor [525611]
Voltage-dependent L-type calcium channel alpha-1D subunit Target Info Inhibitor [533719]
Alpha-1D adrenergic receptor Target Info Inhibitor [533638]
Voltage-dependent L-type calcium channel subunit alpha-1C Target Info Inhibitor [525611]
Alpha-1B adrenergic receptor Target Info Inhibitor [533638]
Alpha-2A adrenergic receptor Target Info Inhibitor [525611]
KEGG Pathway cGMP-PKG signaling pathway
Neuroactive ligand-receptor interactionhsa04020:Calcium signaling pathway
Neuroactive ligand-receptor interaction
AMPK signaling pathway
Adrenergic signaling in cardiomyocytes
Vascular smooth muscle contraction
Salivary secretionhsa04022:cGMP-PKG signaling pathway
Neuroactive ligand-receptor interactionhsa04010:MAPK signaling pathway
Calcium signaling pathway
cAMP signaling pathway
Cardiac muscle contraction
Circadian entrainment
Retrograde endocannabinoid signaling
Glutamatergic synapse
Cholinergic synapse
Serotonergic synapse
GABAergic synapse
Dopaminergic synapse
Insulin secretion
GnRH signaling pathway
Oxytocin signaling pathway
Type II diabetes mellitus
Carbohydrate digestion and absorption
Alzheimer's disease
Amphetamine addiction
Hypertrophic cardiomyopathy (HCM)
Arrhythmogenic right ventricular cardiomyopathy (ARVC)
Dilated cardiomyopathyhsa04020:Calcium signaling pathway
Salivary secretionhsa04010:MAPK signaling pathway
Long-term potentiation
NetPath Pathway IL2 Signaling PathwayNetPath_14:IL2 Signaling PathwayNetPath_14:IL2 Signaling Pathway
PANTHER Pathway Alpha adrenergic receptor signaling pathway
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathwayP00002:Alpha adrenergic receptor signaling pathwayP00002:Alpha adrenergic receptor signaling pathway
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathwayP00003:Alzheimer disease-amyloid secretase pathway
Nicotinic acetylcholine receptor signaling pathway
5HT2 type receptor mediated signaling pathway
Beta1 adrenergic receptor signaling pathway
Beta2 adrenergic receptor signaling pathway
Oxytocin receptor mediated signaling pathwayP00003:Alzheimer disease-amyloid secretase pathway
Oxytocin receptor mediated signaling pathway
Nicotine pharmacodynamics pathwayP00002:Alpha adrenergic receptor signaling pathwayP00002:Alpha adrenergic receptor signaling pathway
Pathway Interaction Database LPA receptor mediated events
PathWhiz Pathway Muscle/Heart Contraction
Reactome Adrenoceptors
Adrenaline signalling through Alpha-2 adrenergic receptor
G alpha (i) signalling events
G alpha (z) signalling eventsR-HSA-390696:Adrenoceptors
G alpha (q) signalling events
G alpha (12/13) signalling eventsR-HSA-390696:Adrenoceptors
Adrenaline,noradrenaline inhibits insulin secretion
G alpha (z) signalling events
Surfactant metabolismR-HSA-400042:Adrenaline,noradrenaline inhibits insulin secretion
NCAM1 interactions
Regulation of insulin secretionR-HSA-390696:Adrenoceptors
G alpha (12/13) signalling eventsR-HSA-400042:Adrenaline,noradrenaline inhibits insulin secretion
Surfactant metabolism
WikiPathways Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Platelet Aggregation (Plug Formation)
GPCR ligand binding
GPCR downstream signalingWP58:Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
Gastrin-CREB signalling pathway via PKC and MAPK
Endothelin Pathways
GPCR downstream signaling
AMPK SignalingWP58:Monoamine GPCRs
Integration of energy metabolism
GPCR downstream signalingWP536:Calcium Regulation in the Cardiac Cell
Arrhythmogenic Right Ventricular Cardiomyopathy
Alzheimers Disease
NCAM signaling for neurite out-growth
Integration of energy metabolismWP58:Monoamine GPCRs
GPCRs, OtherWP536:Calcium Regulation in the Cardiac Cell
Nicotine Activity on Chromaffin CellsWP58:Monoamine GPCRs
Vitamin D Receptor Pathway
References
Ref 468115(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 498).
Ref 546179Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800006771)
Ref 525611Bioorg Med Chem Lett. 1999 Oct 4;9(19):2843-8.Design and synthesis of novel dihydropyridine alpha-1a antagonists.
Ref 533638J Med Chem. 1995 Sep 15;38(19):3681-716.Alpha- and beta-adrenoceptors: from the gene to the clinic. 2. Structure-activity relationships and therapeutic applications.
Ref 533719J Med Chem. 1995 May 12;38(10):1579-81.Discovery of alpha 1a-adrenergic receptor antagonists based on the L-type Ca2+ channel antagonist niguldipine.

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