Drug General Information
Drug ID	D06TVC
Former ID	DIB000174
Drug Name	Tienoxolol
Synonyms	UP-788-42
Drug Type	Small molecular drug
Indication	Hypertension [ICD9: 401; ICD10:I10-I16]		Discontinued in Phase 2	[544571]
Company	Laboratories UPSA
Structure		Download 2D MOL 3D MOL
Formula	C21H28N2O5S
Canonical SMILES	c1(C(=O)OCC)c(OCC(CNC(C)(C)C)O)ccc(NC(=O)c2sccc2)c1
CAS Number	CAS 90055-97-3
PubChem Compound ID	65678
Target and Pathway
Target(s)	Beta-3 adrenergic receptor	Target Info	Modulator	[533973]
KEGG Pathway	Calcium signaling pathway
	cGMP-PKG signaling pathway
	Neuroactive ligand-receptor interaction
	Endocytosis
	Salivary secretion
PANTHER Pathway	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
	Beta3 adrenergic receptor signaling pathway
Reactome	Adrenoceptors
	G alpha (s) signalling events
WikiPathways	Monoamine GPCRs
	Calcium Regulation in the Cardiac Cell
	GPCRs, Class A Rhodopsin-like
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 544571	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000171)
Ref 533973	Effects of the beta-adrenoceptor antagonists atenolol and propranolol on human parotid and submandibular-sublingual salivary secretion. J Dent Res. 1994 Jan;73(1):5-10.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.