Drug Information

Drug General Information
Drug ID
D07BCO
Former ID
DNC001509
Drug Name
WAY-100635
Drug Type
Small molecular drug
Indication Eating disorder [ICD9: 278, 307.5, 401, 428.0; ICD10:E66, F50, I10-I16, I50] Terminated [542914], [545310]
Structure
Download
2D MOL

3D MOL
Formula
C25H34N4O2
InChI
InChI=1S/C25H34N4O2/c1-31-23-12-6-5-11-22(23)28-18-15-27(16-19-28)17-20-29(24-13-7-8-14-26-24)25(30)21-9-3-2-4-10-21/h5-8,11-14,21H,2-4,9-10,15-20H2,1H3
InChIKey
SBPRIAGPYFYCRT-UHFFFAOYSA-N
CAS Number
CAS 146714-97-8
PubChem Compound ID
5684
PubChem Substance ID
5450228, 7980890, 8153485, 11111964, 14856089, 29224721, 47736663, 47885576, 48110625, 49957645, 50111272, 53789487, 77798686, 85208883, 90340807, 103202618, 103817218, 103856046, 103943539, 104309953, 117568341, 124750337, 124881811, 129212842, 135651215, 135651321, 136349538, 136352757, 136367669, 142456119, 152258190, 152344121, 160647026, 162038085, 162108920, 162202772, 164766157, 172919870, 185998777, 198938426, 226462650, 252473864
Target and Pathway
Target(s) 5-hydroxytryptamine 1A receptor Target Info Antagonist [535073], [535298], [535456]
KEGG Pathway cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT1 type receptor mediated signaling pathway
Reactome Serotonin receptors
G alpha (i) signalling events
WikiPathways Serotonin HTR1 Group and FOS Pathway
SIDS Susceptibility Pathways
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 542914(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 80).
Ref 545310Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002783)
Ref 535073Involvement of 5-hydroxytryptamine(1A) receptors in nicotine-induced tail tremor in rats. Eur J Pharmacol. 2000 Nov 10;408(1):19-23.
Ref 535298Cocaine and serotonin: a role for the 5-HT(1A) receptor site in the mediation of cocaine stimulant effects. Behav Brain Res. 2001 Nov 29;126(1-2):127-33.
Ref 5354565-Hydroxytryptamine1A receptor occupancy by novel full antagonist 2-[4-[4-(7-chloro-2,3-dihydro-1,4-benzdioxyn-5-yl)-1-piperazinyl]butyl]-1,2-benzisothiazol-3-(2H)-one-1,1-dioxide: a[11C][O-methyl-3H]-N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide trihydrochloride (WAY-100635) positron emission tomography study in humans. J Pharmacol Exp Ther. 2002 Jun;301(3):1144-50.

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