Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0H0IA
|
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| Former ID |
DIB005487
|
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| Drug Name |
WY-28342
|
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| Indication | Rheumatoid arthritis [ICD9: 710-719, 714; ICD10:M05-M06] | Terminated | [1] | ||
| Company |
Wyeth-Ayerst International Inc
|
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| Structure |
|
Download2D MOL |
|||
| Canonical SMILES |
n1c(c(cc2c1CCCCC2)C)C(c1ccc(cc1)C)O
|
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| CAS Number |
CAS 127890-54-4
|
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| Target and Pathway | |||||
| Target(s) | Cyclooxygenase | Target Info | Modulator | [2] | |
| Arachidonate 5-lipoxygenase | Target Info | Modulator | [2] | ||
| BioCyc Pathway | Aspirin-triggered lipoxin biosynthesis | ||||
| Resolvin D biosynthesis | |||||
| Leukotriene biosynthesis | |||||
| Lipoxin biosynthesis | |||||
| Aspirin triggered resolvin D biosynthesis | |||||
| Aspirin triggered resolvin E biosynthesis | |||||
| KEGG Pathway | Arachidonic acid metabolism | ||||
| Metabolic pathways | |||||
| Serotonergic synapse | |||||
| Ovarian steroidogenesis | |||||
| Toxoplasmosis | |||||
| NetPath Pathway | IL4 Signaling Pathway | ||||
| PathWhiz Pathway | Arachidonic Acid Metabolism | ||||
| WikiPathways | Vitamin D Receptor Pathway | ||||
| Arachidonic acid metabolism | |||||
| Eicosanoid Synthesis | |||||
| Selenium Micronutrient Network | |||||
| References | |||||
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800005582) | ||||
| REF 2 | Synthesis and antiinflammatory activity of certain 5,6,7,8-tetrahydroquinolines and related compounds. J Med Chem. 1995 Apr 28;38(9):1473-81. | ||||
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