Drug Information

Drug General Information
Drug ID
D0OP8W
Former ID
DIB016226
Drug Name
Zalospirone
Synonyms
Zalospirone hydrochloride; Wy-47846
Drug Type
Small molecular drug
Indication Anxiety disorder [ICD9: 300, 311; ICD10:F32, F40-F42] Phase 2 [533189], [541119]
Company
Wyeth
Structure
Download
2D MOL

3D MOL
Formula
C24H29N5O2
InChI
InChI=1S/C24H29N5O2/c30-22-20-18-6-7-19(17-5-4-16(17)18)21(20)23(31)29(22)11-2-1-10-27-12-14-28(15-13-27)24-25-8-3-9-26-24/h3-9,16-21H,1-2,10-15H2/t16-,17+,18-,19+,20-,21+
InChIKey
AERLHOTUXIJQFV-RCPZPFRWSA-N
PubChem Compound ID
163925
PubChem Substance ID
46238242, 57350249, 80453343, 103065081, 103080827, 113452809, 117591930, 135119029, 135651354, 137172945, 180371859, 226597199
Target and Pathway
Target(s) 5-hydroxytryptamine 1A receptor Target Info Agonist [533189]
KEGG Pathway cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT1 type receptor mediated signaling pathway
Reactome Serotonin receptors
G alpha (i) signalling events
WikiPathways Serotonin HTR1 Group and FOS Pathway
SIDS Susceptibility Pathways
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 533189The serotonin 5-HT?? receptor agonist tandospirone improves executive function in common marmosets. Behav Brain Res. 2015 Jul 1;287:120-6.
Ref 541119(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 58).
Ref 533189The serotonin 5-HT?? receptor agonist tandospirone improves executive function in common marmosets. Behav Brain Res. 2015 Jul 1;287:120-6.

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