Drug Information

Drug General Information
Drug ID
D03PDY
Former ID
DNC001298
Drug Name
SB-332235
Drug Type
Small molecular drug
Indication Chronic obstructive pulmonary disease [ICD9: 490-492, 494-496; ICD10:J40-J44, J47] Discontinued in Phase 1 [547219]
Company
GlaxoSmithKline
Structure
Download
2D MOL

3D MOL
Formula
C13H10Cl3N3O4S
Canonical SMILES
C1=CC(=C(C(=C1)Cl)Cl)NC(=O)NC2=C(C(=C(C=C2)Cl)S(=O)(=O)<br />N)O
InChI
1S/C13H10Cl3N3O4S/c14-6-2-1-3-8(10(6)16)18-13(21)19-9-5-4-7(15)12(11(9)20)24(17,22)23/h1-5,20H,(H2,17,22,23)(H2,18,19,21)
InChIKey
WTLRWOHEKQGKDS-UHFFFAOYSA-N
CAS Number
CAS 276702-15-9
PubChem Compound ID
9887803
PubChem Substance ID
14855342, 24174054, 45634742, 49684212, 53790519, 76587477, 129631760, 134340252, 134340503, 135357762, 138061977, 223812643, 227736351
Target and Pathway
Target(s) High affinity interleukin-8 receptor B Target Info Antagonist [536223]
KEGG Pathway Cytokine-cytokine receptor interaction
Chemokine signaling pathway
Endocytosis
Epithelial cell signaling in Helicobacter pylori infection
NetPath Pathway TNFalpha Signaling Pathway
PANTHER Pathway Inflammation mediated by chemokine and cytokine signaling pathway
Interleukin signaling pathway
Pathway Interaction Database IL8- and CXCR2-mediated signaling events
Reactome Chemokine receptors bind chemokines
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 547219Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800014165)
Ref 536223Emerging drugs for the treatment of chronic obstructive pulmonary disease. Expert Opin Emerg Drugs. 2006 May;11(2):275-91.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.