Drug Information

Drug General Information
Drug ID
D00KIE
Former ID
DIB015508
Drug Name
Ensaculin hydrochloride
Synonyms
Anseculin hydrochloride < former INN >; Ensaculin hydrochloride < Prop INN >; KA-672.HCl; 7-Methoxy-6-[3-[4-(2-methoxyphenyl)piperazin-1-yl]propoxy]-3,4-dimethyl-2H-1-benzopyran-2-one hydrochloride
Drug Type
Small molecular drug
Indication Parkinson's disease [ICD9: 332; ICD10:G20] Phase 2 [526403]
Structure
Download
2D MOL

3D MOL
Formula
C26H33ClN2O5
Canonical SMILES
CC1=C(C(=O)OC2=CC(=C(C=C12)OCCCN3CCN(CC3)C4=CC=CC=C4OC)<br />OC)C.Cl
InChI
1S/C26H32N2O5.ClH/c1-18-19(2)26(29)33-23-17-24(31-4)25(16-20(18)23)32-15-7-10-27-11-13-28(14-12-27)21-8-5-6-9-22(21)30-3;/h5-6,8-9,16-17H,7,10-15H2,1-4H3;1H
InChIKey
XMONKHCPLIYQCY-UHFFFAOYSA-N
CAS Number
CAS 155773-59-4
PubChem Compound ID
6918282
PubChem Substance ID
12014917, 14883835, 17194787, 43529664, 49889575, 50142377, 114787721, 135346606, 136922692
Target and Pathway
Target(s) 5-hydroxytryptamine 1A receptor Target Info Modulator [526403]
KEGG Pathway cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT1 type receptor mediated signaling pathway
Reactome Serotonin receptors
G alpha (i) signalling events
WikiPathways Serotonin HTR1 Group and FOS Pathway
SIDS Susceptibility Pathways
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 526403Ensaculin (KA-672 HCl): a multitransmitter approach to dementia treatment. CNS Drug Rev. 2002 Summer;8(2):143-58.
Ref 526403Ensaculin (KA-672 HCl): a multitransmitter approach to dementia treatment. CNS Drug Rev. 2002 Summer;8(2):143-58.

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