Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D00CQW
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| Former ID |
DIB008437
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| Drug Name |
TNP-351
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| Synonyms |
N-[4-[3-(2,4-Diamino-7H-pyrrolo[2,3-d]pyrimidin-5-yl)propyl]benzoyl]-L-glutamic acid
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| Drug Type |
Small molecular drug
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| Indication | Solid tumours [ICD9: 140-199, 210-229; ICD10:C00-D48] | Discontinued in Phase 2 | [545242] | ||
| Structure |
|
Download2D MOL |
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| Formula |
C21H24N6O5
|
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| Canonical SMILES |
C1=CC(=CC=C1CCCC2=CNC3=C2C(=NC(=N3)N)N)C(=O)NC(CCC(=O)O<br />)C(=O)O
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| InChI |
1S/C21H24N6O5/c22-17-16-13(10-24-18(16)27-21(23)26-17)3-1-2-11-4-6-12(7-5-11)19(30)25-14(20(31)32)8-9-15(28)29/h4-7,10,14H,1-3,8-9H2,(H,25,30)(H,28,29)(H,31,32)(H5,22,23,24,26,27)/t14-/m0/s1
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| InChIKey |
WLGCEMWNUHSIIS-AWEZNQCLSA-N
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| CAS Number |
CAS 125991-51-7
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| PubChem Compound ID | |||||
| PubChem Substance ID | |||||
| Target and Pathway | |||||
| Target(s) | DHFR | Target Info | Inhibitor | [526176] | |
| PANTHER Pathway | Tetrahydrofolate biosynthesis | ||||
| Formyltetrahydroformate biosynthesis | |||||
| Pathway Interaction Database | E2F transcription factor network | ||||
| PathWhiz Pathway | Folate Metabolism | ||||
| Pterine Biosynthesis | |||||
| References | |||||
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