TTD | Drug: D0B5PU

Drug General Information
Drug ID	D0B5PU
Former ID	DNC004515
Drug Name	BMS-193884
Drug Type	Small molecular drug
Indication	Pulmonary arterial hypertension [ICD9: 416; ICD10:I27.0, I27.2]		Discontinued in Phase 2	[546390]
Structure		Download 2D MOL 3D MOL
Formula	C20H17N3O4S
Canonical SMILES	CC1=C(ON=C1C)NS(=O)(=O)C2=CC=CC=C2C3=CC=C(C=C3)C4=NC=CO<br />4
InChI	1S/C20H17N3O4S/c1-13-14(2)22-27-19(13)23-28(24,25)18-6-4-3-5-17(18)15-7-9-16(10-8-15)20-21-11-12-26-20/h3-12,23H,1-2H3
InChIKey	LJGUZUROJOJEMI-UHFFFAOYSA-N
PubChem Compound ID	9843631
Target and Pathway
Target(s)	Endothelin-1 receptor	Target Info	Modulator
KEGG Pathway	Calcium signaling pathway
	cGMP-PKG signaling pathway
	cAMP signaling pathway
	Neuroactive ligand-receptor interaction
	Vascular smooth muscle contraction
	Renin secretion
	Pathways in cancer
NetPath Pathway	IL4 Signaling Pathway
PANTHER Pathway	Endothelin signaling pathway
Pathway Interaction Database	Endothelins
Pathway Interaction Database	EGFR-dependent Endothelin signaling events
Reactome	Peptide ligand-binding receptors
Reactome	G alpha (q) signalling events
WikiPathways	Prostaglandin Synthesis and Regulation
	GPCRs, Class A Rhodopsin-like
	Gastrin-CREB signalling pathway via PKC and MAPK
	Peptide GPCRs
	Endothelin Pathways
	GPCR ligand binding
	GPCR downstream signaling
	GPCRs, Other
References
Ref 546390	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800007870)

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Drug Information