Drug Information

Drug General Information
Drug ID
D0R3WG
Former ID
DIB007666
Drug Name
SILPERISONE HYDROCHLORIDE
Synonyms
RGH-5002; SILA-336; Silperisone hydrochloride < Prop INN >; 1-[(4-Fluorobenzyl)dimethylsilylmethyl]piperidine hydrochloride
Drug Type
Small molecular drug
Indication Spasm [ICD9: 728.85; ICD10:R25.2] Discontinued in Phase 2 [545273]
Structure
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2D MOL

3D MOL
Formula
C15H25ClFNSi
Canonical SMILES
C[Si](C)(CC1=CC=C(C=C1)F)CN2CCCCC2.Cl
InChI
1S/C15H24FNSi.ClH/c1-18(2,13-17-10-4-3-5-11-17)12-14-6-8-15(16)9-7-14;/h6-9H,3-5,10-13H2,1-2H3;1H
InChIKey
VGKGHWXDGBFJTP-UHFFFAOYSA-N
CAS Number
CAS 140944-30-5
PubChem Compound ID
178567
PubChem Substance ID
10258958, 14922986, 33501810, 77945380, 104427382, 126448719, 135155474, 224957159, 231474678
Target and Pathway
Target(s) Sodium channel Target Info Modulator [527704], [551871]
KEGG Pathway Dopaminergic synapse
Reactome Interaction between L1 and Ankyrins
References
Ref 545273Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002660)
Ref 527704Tolperisone-type drugs inhibit spinal reflexes via blockade of voltage-gated sodium and calcium channels. J Pharmacol Exp Ther. 2005 Dec;315(3):1237-46. Epub 2005 Aug 26.
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015

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